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醫師介紹

  •

張國軒醫師

多發性硬化症、泛視神經脊髓炎、巴金森氏病、亨丁頓氏舞蹈症、脊髓小腦萎縮症、神經退化性疾病、遺傳性神經病變、幹細胞醫學、細胞生物學、神經肌肉超音波
  • 國語,英語,閩南語
  • 教授
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醫師資歷
  • 現職
    • 林口長庚紀念醫院神經內科教授
    • 長庚大學醫學系教授
    • PACTRIMS (Pan-Asian Committee for Treatment and Research in Multiple Sclerosis) 教育委員
    • 台灣神經學學會理事
    • 台灣神經免疫醫學會常務理事暨學術主任委員
    • 台灣神經罕見疾病學會理事
    • 林口長庚紀念醫院出院準備委員會主席
    • 北區健保署醫藥審查專家
    • 國健署罕病審查專家
  • 學歷
    • 倫敦帝國理工學院醫學博士 (主修幹細胞生物學)
    • 台北醫學大學醫學系醫學士
  • 經歷
    • 台灣動作障礙學會秘書長
    • 英國倫敦Hammersmith hospital 研究員
  • 學會與認證
    • 台灣神經學學會
    • 台灣神經免疫醫學會
    • 台灣神經罕見疾病學會
    • 台灣動作障礙學會
    • 神經科專科醫師證書
    • 神經重症專科醫師證書
  • 論文及期刊發表
    • Heterogeneous Integration of Memristive and Piezoresistive MDMO-PPV-Based Copolymers in Nociceptive Transmission with Fast and Slow Pain for an Artificial Pain-Perceptual System.
      Small. Jun 2024, 2311040. https://doi.org/10.1002/smll.202311040.
      Shih-Cheng Tsao, Kuo-Hsuan Chang, Yi Fu, Han-Hsiang Tai, Ting-Han Lin, Ming-Chung Wu, and Jer-Chyi Wang*
    • The Role of NRF2 in Trinucleotide Repeat Expansion Disorders.
      Antioxidants. Jun 2024, 13, 649. https://doi.org/10.3390/antiox13060649.
      Kuo-Hsuan Chang, Chiung-Mei Chen*.
    • Identification of blood metabolic biomarkers associated with diabetic distal symmetric sensorimotor polyneuropathy in patients with type 2 diabetes mellitus.
      J Peripher Nerv Syst. 2023 Dec;28(4):651-663. doi: 10.1111/jns.12600. Epub 2023 Oct 21.
      Kuo-Hsuan Chang, Chiung-Mei Chen, Chia-Ni Lin, Sung-Sheng Tsai, Rong-Kuo Lyu, Chun-Che Chu, Long-Sun Ro, Ming-Feng Liao, Hong-Shiu Chang, Yi-Ching Weng, Jawl-Shan Hwang, Hung-Chou Kuo*.
    • A Neuroprotective Action of Quercetin and Apigenin through Inhibiting Aggregation of Aβ and Activation of TRKB Signaling in a Cellular Experiment.
      Biomol Ther (Seoul). 2023 May 1;31(3):285-297. doi: 10.4062/biomolther.2022.136. Epub 2023 Jan 17.
      Ya-Jen Chiu, Yu-Shan Teng, Chiung-Mei Chen, Ying-Chieh Sun, Hsiu Mei Hsieh-Li, Kuo-Hsuan Chang*, Guey-Jen Lee-Chen*.
    • Upregulation of APAF1 and CSF1R in Peripheral Blood Mononuclear Cells of Parkinson's Disease.
      Int J Mol Sci. 2023 Apr 12;24(8):7095. doi: 10.3390/ijms24087095.
      Kuo-Hsuan Chang, Chia-Hsin Liu, Yi-Ru Wang, Yen-Shi Lo, Chun-Wei Chang, Hsiu-Chuan Wu, Chiung-Mei Chen*.
    • Investigating Therapeutic Effects of Indole Derivatives Targeting Inflammation and Oxidative Stress in Neurotoxin-Induced Cell and Mouse Models of Parkinson's Disease.
      Int J Mol Sci. 2023 Jan 30;24(3):2642. doi: 10.3390/ijms24032642.
      Ya-Jen Chiu, Chih-Hsin Lin, Chung-Yin Lin, Pei-Ning Yang, Yen-Shi Lo, Yu-Chieh Chen, Chiung-Mei Chen, Yih-Ru Wu, Ching-Fa Yao, Kuo-Hsuan Chang*, Guey-Jen Lee-Chen*.
    • Alternations of Lipoprotein Profiles in the Plasma as Biomarkers of Huntington's Disease.
      Cells. 2023 Jan 20;12(3):385. doi: 10.3390/cells12030385.
      Kuo-Hsuan Chang, Mei-Ling Cheng, Chi-Jen Lo, Chun-Ming Fan, Yih-Ru Wu, Chiung-Mei Chen*.
    • Using ΔK280 TauRD Folding Reporter Cells to Screen TRKB Agonists as Alzheimer's Disease Treatment Strategy.
      Biomolecules. 2023 Jan 23;13(2):219. doi: 10.3390/biom13020219.
      Zheng-Kui Weng, Te-Hsien Lin, Kuo-Hsuan Chang, Ya-Jen Chiu, Chih-Hsin Lin, Pei-Hsuan Tseng, Ying-Chieh Sun, Wenwei Lin, Guey-Jen Lee-Chen*, Chiung-Mei Chen*.
    • Neuroprotective Action of Coumarin Derivatives through Activation of TRKB-CREB-BDNF Pathway and Reduction of Caspase Activity in Neuronal Cells Expressing Pro-Aggregated Tau Protein.
      Int J Mol Sci. 2022 Oct 22;23(21):12734. doi: 10.3390/ijms232112734.
      Te-Hsien Lin, Kuo-Hsuan Chang, Ya-Jen Chiu, Zheng-Kui Weng, Ying-Chieh Sun, Wenwei Lin, Guey-Jen Lee-Chen*, Chiung-Mei Chen*.
    • Establishment of a new classification system for chronic inflammatory demyelinating polyneuropathy based on unsupervised machine learning.
      Muscle Nerve. 2022 Nov;66(5):603-611. doi: 10.1002/mus.27702. Epub 2022 Aug 27.
      Chun-Wei Chang, Long-Sun Ro*, Rong-Kuo Lyu, Hung-Chou Kuo, Ming-Feng Liao, Yih-Ru Wu, Chiung-Mei Chen, Hong-Shiu Chang, Yi-Ching Weng, Chin-Chang Huang, Kuo-Hsuan Chang*.
    • Clinical Characteristics and Prognostic Factors of Non-Infectious Cerebral Venous Sinus Thrombosis.
      J Clin Med. 2022 Oct 16;11(20):6096. doi: 10.3390/jcm11206096.
      Yu-Chieh Chen, Chun-Wei Chang, Hsiu-Chuan Wu, Chiung-Mei Chen, Chien-Hung Chang, Kuo-Hsuan Chang*.
    • Isorhamnetin Attenuated the Release of Interleukin-6 from β- Amyloid-Activated Microglia and Mitigated Interleukin-6- Mediated Neurotoxicity.
      Oxid Med Cell Longev. 2022 Sep 15:2022:3652402. doi: 10.1155/2022/3652402. eCollection 2022.
      Pei-Cih Wei, Guey-Jen Lee-Chen, Chiung-Mei Chen, Ying Chen, Yen-Shi Lo, Kuo-Hsuan Chang*.
    • Evaluating the Different Stages of Parkinson's Disease Using Electroencephalography With Holo-Hilbert Spectral Analysis.
      Front Aging Neurosci. 2022 May 10:14:832637. doi: 10.3389/fnagi.2022.832637. eCollection 2022.
      Kuo-Hsuan Chang, Isobel Timothea French, Wei-Kuang Liang, Yen-Shi Lo, Yi-Ru Wang, Mei-Ling Cheng, Norden E Huang, Hsiu-Chuan Wu, Siew-Na Lim, Chiung-Mei Chen*, Chi-Hung Juan*.
    • Major Bleeding Risk in Atrial Fibrillation Patients Co-Medicated With Non-Vitamin K Oral Anticoagulants and Antipsychotics.
      Front Pharmacol. 2022 Apr 14:13:819878. doi: 10.3389/fphar.2022.819878. eCollection 2022.
      Chiung-Mei Chen, Kuo-Hsuan Chang, Chun-Li Wang, Hui-Tzu Tu, Yu-Tung Huang, Hsiu-Chuan Wu, Chien-Hung Chang, Shang-Hung Chang*.
    • Biomarker of Neuroinflammation in Parkinson's Disease.
      Int J Mol Sci. 2022 Apr 8;23(8):4148. doi: 10.3390/ijms23084148.
      Tsai-Wei Liu, Chiung-Mei Chen, Kuo-Hsuan Chang*.
    • Major Bleeding Risk in Patients With Non-valvular Atrial Fibrillation Concurrently Taking Direct Oral Anticoagulants and Antidepressants.
      Front Aging Neurosci. 2022 Feb 4:14:791285. doi: 10.3389/fnagi.2022.791285. eCollection 2022.
      Kuo-Hsuan Chang, Chiung-Mei Chen, Chun-Li Wang, Hui-Tzu Tu, Yu-Tung Huang, Hsiu-Chuan Wu, Chien-Hung Chang, Shang-Hung Chang*.
    • Alterations of Sphingolipid and Phospholipid Pathways and Ornithine Level in the Plasma as Biomarkers of Parkinson's Disease.
      Cells. 2022 Jan 24;11(3):395. doi: 10.3390/cells11030395.
      Kuo-Hsuan Chang, Mei-Ling Cheng, Hsiang-Yu Tang, Cheng-Yu Huang, Hsiu-Chuan Wu, Chiung-Mei Chen*.
    • Altered Metabolic Profiles of the Plasma of Patients with Amyotrophic Lateral Sclerosis.
      Biomedicines. 2021 Dec 18;9(12):1944. doi: 10.3390/biomedicines9121944.
      Kuo-Hsuan Chang, Chia-Ni Lin, Chiung-Mei Chen, Rong-Kuo Lyu, Chun-Che Chu, Ming-Feng Liao, Chin-Chang Huang, Hong-Shiu Chang, Long-Sun Ro, Hung-Chou Kuo*.
    • Alterations of Plasma Galectin-3 and C3 Levels in Patients with Parkinson's Disease.
      Brain Sci. 2021 Nov 15;11(11):1515. doi: 10.3390/brainsci11111515.
      Hsiu-Chuan Wu, Kuo-Hsuan Chang, Mu-Chun Chiang, Chiung-Mei Chen*.
    • Multi-Target Effects of Novel Synthetic Coumarin Derivatives Protecting Aβ-GFP SH-SY5Y Cells against A Toxicity.
      Cells. 2021 Nov 9;10(11):3095. doi: 10.3390/cells10113095.
      Ching-Chia Huang, Kuo-Hsuan Chang, Ya-Jen Chiu, Yi-Ru Chen, Tsai-Hui Lung, Hsiu Mei Hsieh-Li, Ming-Tsan Su, Ying-Chieh Sun, Chiung-Mei Chen*, Wenwei Lin*, Guey-Jen Lee-Chen*.
    • Novel Synthetic Coumarin-Chalcone Derivative (E)-3-(3-(4- (Dimethylamino)Phenyl)Acryloyl)-4-Hydroxy-2H-Chromen-2- One Activates CREB-Mediated Neuroprotection in Aβ and Tau Cell Models of Alzheimer's Disease.
      Oxid Med Cell Longev. 2021 Nov 13:2021:3058861. doi: 10.1155/2021/3058861. eCollection 2021.
      Ya-Jen Chiu, Te-Hsien Lin, Chiung-Mei Chen, Chih-Hsin Lin, Yu-Shan Teng, Chung-Yin Lin, Ying-Chieh Sun, Hsiu Mei Hsieh-Li, Ming-Tsan Su, Guey-Jen Lee-Chen*, Wenwei Lin*, Kuo-Hsuan Chang*.
    • Assessing Plasma Levels of α-Synuclein and Neurofilament Light Chain by Different Blood Preparation Methods.
      Front Aging Neurosci. 2021 Nov 8:13:759182. doi: 10.3389/fnagi.2021.759182. eCollection 2021.
      Kuo-Hsuan Chang, Kou-Chen Liu, Chao-Sung Lai, Shieh-Yueh Yang, Chiung-Mei Chen*.
    • In vitro genome editing rescues parkinsonism phenotypes in induced pluripotent stem cells?derived dopaminergic neurons carrying LRRK2 p.G2019S mutation.
      Stem Cell Res Ther. 2021 Sep 22;12(1):508. doi: 10.1186/s13287-021-02585-2.
      Kuo-Hsuan Chang, Cheng-Yen Huang, Chih-Hsin Ou-Yang, Chang-Han Ho, Han-Yi Lin, Chia-Lang Hsu, You-Tzung Chen, Yu-Chi Chou, Yi-Jing Chen, Ying Chen, Jia-Li Lin, Ji-Kuan Wang, Pei-Wen Lin, Ying-Ru Lin, Miao-Hsia Lin, Chi-Kang Tseng, Chin-Hsien Lin*.
    • Reaction-inhibited interfacial coating between PEDOT:PSS sensing membrane and ITO electrode for highly-reliable piezoresistive pressure sensing applications.
      Journal of the Taiwan Institute of Chemical Engineers. Volume 126, September 2021, Pages 297-306. https://doi.org/10.1016/j.jtice.2021.07.004
      Jer-Chyi Wang*, Rajat Subhra Karmakar, Ting-Han Lin, Ming-Chung Wu*, Kuo-Hsuan Chang*.
    • Formulated Chinese medicine Shaoyao Gancao Tang reduces NLRP1 and NLRP3 in Alzheimer’s disease cell and mouse models for neuroprotection and cognitive improvement.
      Aging (Albany NY). 2021 Jun 9;13(11):15620-15637. doi: 10.18632/aging.203125. Epub 2021 Jun 9.
      Ya-Jen Chiu, Chih-Hsin Lin, Ming-Chung Lee, Hsiu Mei Hsieh-Li, Chiung-Mei Chen, Yih-Ru Wu, Kuo-Hsuan Chang*, Guey-Jen Lee-Chen*.
    • Characteristics of ischemic stroke and intracranial hemorrhage in patients with nephrotic syndrome.
      BMC Nephrol. 2021 Jun 5;22(1):213. doi: 10.1186/s12882-021-02415-w.
      Wen-Yi Huang, Chun-Wei Chang, Chiung-Mei Chen, Kuan-Hsing Chen, Chien-Hung Chang, Hsiu-Chuan Wu, Kuo-Hsuan Chang*.
    • Correlations among disability, anti-AQP4 antibody status and prognosis in the spinal cord involved patients with NMOSD.
      BMC Neurol. 2021 Apr 9;21(1):153. doi: 10.1186/s12883-021-02171-2.
      Jung Lung Hsu, Ming-Feng Liao, Kuo-Hsuan Chang, Mei-Yun Cheng, Long-Sun Ro*.
    • Reappraisal of the incidence, various types and risk factors of malignancies in patients with dermatomyositis and polymyositis in Taiwan.
      Sci Rep. 2021 Feb 25;11(1):4545. doi: 10.1038/s41598-021-83729-5.
      Jung-Lung Hsu#, Ming-Feng Liao#, Chun-Che Chu, Hung-Chou Kuo, Rong-Kuo Lyu, Hong-Shiu Chang, Chiung-Mei Chen, Yih-Ru Wu, Kuo-Hsuan Chang, Yi-Ching Weng, Chun-Wei Chang, Hsing-I Chiang, Chih-Kuang Cheng, Pai-Wei Lee, Chin-Chang Huang, Long-Sun Ro*.
    • Pathomechanism Characterization and Potential Therapeutics Identification for Parkinson's Disease Targeting Neuroinflammation.
      Int J Mol Sci. 2021 Jan 21;22(3):1062. doi: 10.3390/ijms22031062.
      Chiung-Mei Chen, Chien-Yu Yen, Wan-Ling Chen, Chih-Hsin Lin, Yih-Ru Wu, Kuo-Hsuan Chang, Guey-Jen Lee-Chen*.
    • Association of SOD2 p.V16A polymorphism with Parkinson's disease: A meta-analysis in Han Chinese.
      J Formos Med Assoc. 2021 Jan;120(1 Pt 2):501-507. doi: 10.1016/j.jfma.2020.06.023. Epub 2020 Jun 30.
      Yih-Ru Wu, Kuo-Hsuan Chang, Chih-Ying Chao, Chih-Hsin Lin, Yi-Chun Chen, Tsai-Wei Liu, Guey-Jen Lee-Chen, Chiung-Mei Chen*.
    • Pathomechanism characterization and potential therapeutics identification for SCA3 targeting neuroinflammation.
      Aging (Albany NY). 2020 Nov 10;12(23):23619-23646. doi: 10.18632/aging.103700. Epub 2020 Nov 10.
      Ya-Jen Chiu, Shu-An Lin, Wan-Ling Chen, Te-Hsien Lin, Chih-Hsin Lin, Ching-Fa Yao, Wenwei Lin, Yih-Ru Wu, Kuo-Hsuan Chang, Guey-Jen Lee-Chen, Chiung-Mei Chen*.
    • Differences in Clinical Presentation of Behavioral and Psychological Symptoms of Dementia in Alzheimer's Disease According to Sex and Education Level.
      J Alzheimers Dis. 2020;78(2):711-719. doi: 10.3233/JAD-200507.
      Kuo-Hsuan Chang, Chin-Chang Huang, Chiung-Mei Chen, Hsiu-Chuan Wu, Hung-Chou Kuo*.
    • Serum levels of cell adhesion molecules in patients with neuromyelitis optica spectrum disorder.
      Ann Clin Transl Neurol. 2020 Oct;7(10):1854-1861. doi: 10.1002/acn3.51167. Epub 2020 Aug 28.
      Bao-Luen Chang, Long-Sun Ro, Chiung-Mei Chen, Yen-Shi Lo, Rong-Kuo Lyu, Hung-Chou Kuo, Ming-Feng Liao, Chun-Wei Chang, Hong-Shiu Chang, Ching-Chang Huang, Yih-Ru Wu, Chun-Che Chu, Yi-Ching Weng, Kuo-Hsuan Chang*.
    • Lactulose and Melibiose Attenuate MPTP-Induced Parkinson's Disease in Mice by Inhibition of Oxidative Stress, Reduction of Neuroinflammation and Up-Regulation of Autophagy.
      Front Aging Neurosci. 2020 Jul 24;12:226. doi: 10.3389/fnagi.2020.00226. eCollection 2020.
      Chih-Hsin Lin, Pei-Cih Wei, Chiung-Mei Chen, Yu-Ting Huang, Jia-Lan Lin, Yen-Shi Lo, Jia-Li Lin, Chung-Yin Lin, Yih-Ru Wu, Kuo-Hsuan Chang*, Guey-Jen Lee-Chen*.
    • Exploration of multi-target effects of 3-benzoyl-5-hydroxychromen-2-one in Alzheimer's disease cell and mouse models.
      Aging Cell. 2020 Jul;19(7):e13169. doi: 10.1111/acel.13169. Epub 2020 Jun 4.
      Te-Hsien Lin, Ya-Jen Chiu, Chih-Hsin Lin, Chung-Yin Lin, Chih-Ying Chao, Yu-Chieh Chen, Shu-Mei Yang, Wenwei Lin, Hsiu Mei Hsieh-Li, Yih-Ru Wu, Kuo-Hsuan Chang, Guey-Jen Lee-Chen, Chiung-Mei Chen*.
    • The Role of Oxidative Stress in Parkinson's Disease.
      Antioxidants 2020, 9, 597; doi:10.3390/antiox9070597.
      Kuo-Hsuan Chang and Chiung-Mei Chen*.
    • Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability.
      Cells. 2020 May 16;9(5):1230. doi: 10.3390/cells9051230.
      Chiung Mei Chen, Chih-Hsin Lin, Yih-Ru Wu, Chien-Yu Yen, Yu-Ting Huang, Jia-Lan Lin, Chung-Yin Lin, Wan-Ling Chen, Chih-Ying Chao, Guey-Jen Lee-Chen*, Ming-Tsan Su*, Kuo-Hsuan Chang*.
    • New Synthetic 3-Benzoyl-5-Hydroxy-2 H-Chromen-2-One (LM-031) Inhibits Polyglutamine Aggregation and Promotes Neurite Outgrowth through Enhancement of CREB, NRF2, and Reduction of AMPK α in SCA17 Cell Models.
      Oxid Med Cell Longev. 2020 Apr 22;2020:3129497. doi: 10.1155/2020/3129497. eCollection 2020.
      Chiung-Mei Chen, Wan-Ling Chen, Shu-Ting Yang, Te-Hsien Lin, Shu-Mei Yang, Wenwei Lin, Chih-Ying Chao, Yih-Ru Wu, Kuo-Hsuan Chang, Guey-Jen Lee-Chen*.
    • Association of genetic variants within HLA-DR region with Parkinson's disease in Taiwan
      Neurobiol Aging. 2020 Mar;87:140.e13-140.e18. doi: 10.1016/j.neurobiolaging.2019.11.002. Epub 2019 Nov 9.
      Kuo-Hsuan Chang, Yih-Ru Wu, Yi-Chun Chen, Hon-Chung Fung, Chiung-Mei Chen*.
    • Computed Tomography Angiography in Acute Stroke Patients Receiving Recombinant Tissue Plasminogen Activator: Outcome and Safety Evaluations in an Asian Population.
      Cerebrovasc Dis. 2020 Feb 5:1-8. doi: 10.1159/000504776. [Epub ahead of print]
      Lin CM, Wu HC, Wu YM, Liu CH, Chang KH, Chang TY, Huang KL, Chang YJ, Lee TH, Tsay PK, Cheng CK, Chang CH*.
    • Neuroprotection of Indole-Derivative Compound NC001-8 by the Regulation of the NRF2 Pathway in Parkinson's Disease Cell Models.
      Oxid Med Cell Longev. 2019 Oct 31;2019:5074367. doi: 10.1155/2019/5074367. eCollection 2019.
      Wei PC, Lee-Chen GJ, Chen CM, Wu YR, Chen YJ, Lin JL, Lo YS, Yao CF, Chang KH*.
    • Pueraria lobata and Daidzein Reduce Cytotoxicity by Enhancing Ubiquitin-Proteasome System Function in SCA3-iPSC-Derived Neurons.
      Oxid Med Cell Longev. 2019 Oct 7;2019:8130481. doi: 10.1155/2019/8130481. eCollection 2019.
      Chen IC, Chang KH, Chen YJ, Chen YC, Lee-Chen GJ, Chen CM*.
    • Association between CSF1 and CSF1R Polymorphisms and Parkinson's Disease in Taiwan.
      J. Clin. Med. 2019, 8(10), 1529; https://doi.org/10.3390/jcm8101529 (registering DOI) - 24 Sep 2019.
      Kuo-Hsuan Chang, Yih-Ru Wu, Yi-Chun Chen, Hsiu-Chuan Wu, Chiung-Mei Chen*.
    • Generation of induced pluripotent stem cells from a young-onset Parkinson'sdisease patient carrying the compound heterozygous PLA2G6 p.D331Y/p.M358IfsX mutations.
      Stem Cell Research. Volume 40, October 2019, 101552. https://doi.org/10.1016/j.scr.2019.101552.
      Chiu CC, Wang HL, Weng YH, Chen RS, Chen CM, Yeh TH, Lu CS, Chen YJ, Liu YC, Huang YZ*, Chang KH*.
    • Clinical and cytokine profile of adult acute necrotizing encephalopathy.
      Biomedical Journal. Volume 42, Issue 3, June 2019, Pages 178-186. https://doi.org/10.1016/j.bj.2019.01.008.
      Yi-Ying Lin, Kuang-Yung Lee, Long-Sun Ro, Yen-Shi Lo, Chin-Chang Huang, Kuo-Hsuan Chang*.
    • Generation of a human iPS cell line (CGMH.SLC26A4919-2) from a Pendred syndrome patient carrying SLC26A4 c.919-2A>G splice-site mutation.
      Stem Cell Research. Available online 31 July 2019, 101524. doi.org/10.1016/j.scr.2019.101524.
      Yen-Fu Cheng, Yen-Hui Chan, Chin-Ju Hu, Ying-Chang Lu, Tsubasa Saeki, Makoto Hosoya, Chika Saegusa, Masato Fujioka, Hideyuki Okano, Shih-Ming Weng, Chuan-Jen Hsu, Kuo-Hsuan Chang*, Chen-Chi Wu*.
    • Gulllain-Barre Syndrome After Trivalent Influenza Vaccination in Adults.
      Front Neurol. 2019 Jul 24;10:768. doi: 10.3389/fneur.2019.00768. eCollection 2019.
      Chang KH, Lyu RK, Lin WT, Huang YT, Lin HS, Chang SH*.
    • A prospective, observational study on conversion of clinically isolated syndrome to multiple sclerosis during 4-year period (MS NEO study) in Taiwan.
      PLoS One. 2019 Jul 15;14(7):e0202453. doi: 10.1371/journal.pone.0202453. eCollection 2019.
      Ro LS, Yang CC, Lyu RK, Lin KP, Tsai TC, Lu SR, Chang KH, Huang LC, Tsai CP*.
    • Modeling Alzheimer's Disease by Induced Pluripotent Stem Cells Carrying APP D678H Mutation.
      Mol Neurobiol. 2019 Jun;56(6):3972-3983. doi: 10.1007/s12035-018-1336-x. Epub 2018 Sep 20.
      Chang KH, Lee-Chen GJ, Huang CC, Lin JL, Chen YJ, Wei PC, Lo YS, Yao CF, Kuo MW, Chen CM*.
    • A comparison between spinal cord infarction and neuromyelitis optica spectrum disorders: Clinical and MRI studies.
      Sci Rep. 2019 May 15;9(1):7435. doi: 10.1038/s41598-019-43606-8.
      Hsu JL, Cheng MY, Liao MF, Hsu HC, Weng YC, Chang KH, Chang HS, Kuo HC, Huang CC, Lyu RK, Lin KJ, Ro LS*.
    • Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease.
      Neurochemistry International. 2019 May;125:175-186. doi: 10.1016/j.neuint.2019.01.021. Epub 2019 Jan 29.
      Chiu YJ, Hsieh YH, Lin TH, Lee GC, Hsieh-Li HM, Sun YC, Chen CM, Chang KH*, Lee-Chen GJ*.
    • Association of Multiple Sclerosis with Psoriasis: A Systematic Review and Meta-Analysis of Observational Studies.
      Am J Clin Dermatol. 2019 Apr;20(2):201-208. doi: 10.1007/s40257-018-0399-9.
      Liu CY, Tung TH, Lee CY, Chang KH, Wang SH, Chi CC*.
    • Shaoyao Gancao Tang (SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models.
      Aging (Albany NY). 2019 Feb 13;11(3):986-1007. doi: 10.18632/aging.101804.
      Chen CM, Chen WL, Hung CT, Lin TH, Lee MC, Chen IC, Lin CH, Chao CY, Wu YR, Chang KH, Hsieh-Li HM, Lee-Chen GJ*.
    • Indole Compound NC009-1 Augments APOE and TRKA in Alzheimer's Disease Cell and Mouse Models for Neuroprotection and Cognitive Improvement.
      J Alzheimers Dis. 2019;67(2):737-756. doi: 10.3233/JAD-180643.
      Chen YC, Chiu YJ, Lin CH, Hsu WC, Wu JL, Huang CH, Lin CW, Yao CF, Huang HJ, Lo YS, Chen CM, Wu YR, Chang KH*, Lee-Chen GJ*, Mei Hsieh-Li H*.
    • Polymorphisms of ACMSD-TMEM163, MCCC1, and BCKDK-STX1B Are Not Associated with Parkinson's Disease in Taiwan.
      Parkinsons Dis. 2019 Jan 2;2019:3489638. doi: 10.1155/2019/3489638. eCollection 2019.
      Chang KH, Chen CM, Chen YC, Fung HC, Wu YR*.
    • Novel synthetic chalcone-coumarin hybrid for Aβ aggregation reduction, antioxidation, and neuroprotection.
      CNS Neurosci Ther. 2018 Dec;24(12):1286-1298. doi: 10.1111/cns.13058. Epub 2018 Sep 14.
      Lee SY, Chiu YJ, Yang SM, Chen CM, Huang CC, Lee-Chen GJ*, Lin W*, Chang KH*.
    • Genetic Polymorphisms Associated with Spontaneous Intracerebral Hemorrhage.
      Int J Mol Sci. 2018 Dec 4;19(12). pii: E3879. doi: 10.3390/ijms19123879.
      Chen YC, Chang KH, Chen CM*.
    • Formulated Chinese Medicine Shaoyao Gancao Tang Reduces Tau Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation.
      Oxid Med Cell Longev. 2018 Oct 28;2018:9595741. doi: 10.1155/2018/9595741. eCollection 2018.
      Chen IC, Lin TH, Hsieh YH, Chao CY, Wu YR, Chang KH, Lee MC, Lee-Chen GJ, Chen CM*.
    • Chinese Herbal Medicine Glycyrrhiza inflataReduces Aβ Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation.
      Am J Chin Med. 2018 Oct 4:1-25. doi: 10.1142/S0192415X18500799. [Epub ahead of print]
      Chiu YJ, Lee CM, Lin TH, Lin HY, Lee SY, Mesri M, Chang KH, Lin JY, Lee-Chen GJ, Chen CM*.
    • Lipophilic antioxidants in neurodegenerative diseases.
      Clin Chim Acta. 2018 Oct;485:79-87. doi: 10.1016/j.cca.2018.06.031. Epub 2018 Jun 22.
      Chang KH, Cheng ML, Chiang MC, Chen CM*.
    • Alternations of Metabolic Profile and Kynurenine Metabolism in the Plasma of Parkinson's Disease.
      Mol Neurobiol. 2018 Aug;55(8):6319-6328. doi: 10.1007/s12035-017-0845-3. Epub 2018 Jan 2.
      Chang KH, Cheng ML, Tang HY, Huang CY, Wu YR, Chen CM*.
    • The indole compound NC009-1 inhibits aggregation and promotes neurite outgrowth through enhancement of HSPB1 in SCA17 cells and ameliorates the behavioral deficits in SCA17 mice.
      Neurotoxicology. 2018 Jun 21;67:259-269. doi: 10.1016/j.neuro.2018.06.009. [Epub ahead of print]
      Chen CM, Chen WL, Hung CT, Lin TH, Chao CY, Lin CH, Wu YR, Chang KH, Yao CF, Lee-Chen GJ*, Su MT*, Hsieh-Li HM*.
    • Genetic and functional characters of GRN p.T487I mutation in Taiwanese patients with atypical parkinsonian disorders.
      Parkinsonism Relat Disord. 2018 Jun;51:61-66. doi: 10.1016/j.parkreldis.2018.02.045. Epub 2018 Feb 28.
      Chang KH, Lee GC, Huang CC, Kuo HC, Chen CM, Hsiao YC, Hsu HC, Hsu KJ, Lin CH, Chang CW, Lee-Chen GJ, Wu YR*.
    • DLG2, but not TMEM229B, GPNMB, and ITGA8 polymorphism, is associated with Parkinson's disease in a Taiwanese population.
      Neurobiol Aging. 2018 Apr;64:158.e1-158.e6. doi: 10.1016/j.neurobiolaging.2017.11.016. Epub 2017 Dec 8.
      Wu HC, Chen CM, Chen YC, Fung HC, Chang KH, Wu YR*.
    • Elevated serum levels of endothelin-1 in patients with chronic inflammatory demyelinating polyneuropathy.
      Clinica Chimica Acta.2018 Jan;476:49-53.
      Chang CW, Wu HC, Lyu RK, Lo YS, Chen CM, Ro LS, Chang HS, Huang CC, Liao MF, Wu YR, Kuo HC, Chu CC, Weng YC, Wei PT, Lo AL, Chang KH*.
    • Down-regulation of miR-9* in the peripheral leukocytes of Huntington's disease patients.
      Orphanet J Rare Dis. 2017 Dec 19;12(1):185. doi: 10.1186/s13023-017-0742-x.
      Chang KH, Wu YR, Chen CM*.
    • Altered Aconitase 2 Activity in Huntington's Disease Peripheral Blood Cells and Mouse Model Striatum.
      Int J Mol Sci. 2017 Nov 21;18(11). pii: E2480. doi: 10.3390/ijms18112480.
      Chen CM*, Wu YR, Chang KH.
    • A prospective, observational study of patients with uncommon distal symmetric painful small-fiber neuropathy.
      PLoS One. 2017 Sep 28;12(9):e0183948. doi: 10.1371/journal.pone.0183948. eCollection 2017.
      Hsu JL, Liao MF, Hsu HC, Weng YC, Lo AL, Chang KH, Chang HS, Kuo HC, Huang CC, Ro LS.
    • Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome.
      Sci Rep. 2017 Aug 15;7(1):8140. doi: 10.1038/s41598-017-08338-7.
      Tang HY, Chiu DT, Lin JF, Huang CY, Chang KH, Lyu RK, Ro LS, Kuo HC, Cheng ML, Chen CM.
    • The Potential of Indole/Indolylquinoline Compounds for Tau Misfolding Reduction by Enhancement of HSPB1
      CNS Neurosci Ther 23: 45-56. (2017)
      Chang KH, Lin CH, Chen HC, Huang HY, Chen SL, Lin TH, Ramesh Chintakunta, Huang CC, Fung HC, Wu YR, Huang HJ, Lee-Chen GJ, Hsieh-Li HM, Yao CF
    • Clinical and electrodiagnostic characteristics of nitrous oxide-induced neuropathy in Taiwan
      Clin Neurophysiol 127: 3288-3293. (2016)
      Li HT, Chu CC, Chang KH, Liao MF, Chang HS, Kuo HC, Lyu RK
    • Increased serum concentrations of transforming growth factor-β1 (TGF-β1) in patients with Guillain-Barre syndrome
      Clin Chim Acta 463: 8-13. (2016)
      Chang KH, Lyu RK, Ro YS, Chen YC, Ro LS, Chang HS, Huang CC, Liao MF, Wu YR, Kuo HC, Chu CC, Chen CM
    • Correlations of clinical, neuroimaging, and electrophysiological features in Hirayama disease
      Medicine 95:e4210. (2016)
      Liao MF, Chang HS, Chang KH, Ro LS, Chu CC, Kuo HC, Lyu RK
    • Functional properties of LRRK2 mutations in Taiwanese Parkinson's disease
      J Formos Med Assoc (in press) (2016)
      Chang, KH, Chen CM, Lin CH, Chang WT, Jiang PR, Hsiao YC, Yih-Ru Wu YR, Guey-Jen Lee-Chen GJ
    • Identifying GSK-3β kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays
      Eur J Pharm Sci 89: 11-9. (2016)
      Lin CH, Hsieh YS, Wu YR, Hsu CJ, Chen HC, Huang WH, Chang KH, Hsieh-Li HM, Su MT, Sun YC, Lee GC, Lee-Chen GJ
    • Impairment of proteasome and anti-oxidative pathways in the induced pluripotent stem cell model for sporadic Parkinson's disease
      Parkinsonism Rel Disord 24: 81-88.(2016)
      Chang KH(Corresponding author), Lee-Chen GJ, Wu YR, Chen YJ, Lin JL, Li M, Chen IC, Lo YS, Wu HC, Chen CM
    • Association of GCH1 and MIR4697, but not SIPA1L2 and VPS13C polymorphisms, with Parkinson's disease in Taiwan
      Neurobiol Aging 211: e1-5. (2016)
      Chen CM, Chen YC, Chiang MC, Fung HC, Chang KH, Lee-Chen GJ, Wu YR
    • The aqueous extract of Glycyrrhiza inflata can up-regulate UPR-mediated chaperones to reduce tau misfolding in cell models of Alzheimer's disease
      Drug Des Devel Ther 10: 885-896.(2016)
      Chang KH, Chen IC, Lin HY, Chen HC, Lin CH, Lin TH, Weng YT, Chao CY, Wu YR, Lin JY, Lee-Chen GJ, Chen CM
    • Metabolic disturbances in plasma as biomarkers for Huntington's disease
      J Nutr Biochem 31: 38-44.(2016)
      Cheng ML, Chang KH(co-first author), Wu YR, Chen CM
    • Eukaryotic translation initiation factor 4-γ, 1 gene mutations are rare in Parkinson's disease among Taiwanese
      J Formos Med Assoc. 115: 728-733.(2016)
      Weng YC, Chen CM, Chen YC, Fung HC, Chang CW, Chang KH, Wu YR
    • Efficacy and safety of topiramate for essential tremor: a meta-analysis of randomized controlled trials
      Medicine (Baltimore) 94(43):e1809.(2015)
      Chang KH, Wang SH, Chi CC
    • STK39, but not BST1, HLA-DQB1, and SPPL2B polymorphism, is associated with Han-Chinese Parkinson's disease in Taiwan
      Medicine (Baltimore). 94(41):e1690.(2015)
      Chang KH, Wu YR, Chen YC, Fung HC, Lee-Chen GJ, Chen CM
    • The potential of synthetic indolylquinoline derivatives for Aβ aggregation reduction by chemical chaperone activity
      Neuropharmacology 101:309-319.(2016)
      Chang KH, Chiu YJ, Chen SL, Huang CH, Lin CH, Lin TH, Lee CM, Ramesh C, Wu CH, Huang CC, Fung HC, Chen YC, Lin JY, Yao CF, Huang HJ, Lee-Chen GJ, Lee MC, Hsieh-Li HM
    • The use of human amniotic fluid mesenchymal stem cells as the feeder layer to establish human embryonic stem cell lines
      Journal of Tissue Engineering and Regenerative Medicine 9(12): e302-e307 (SCI)(2015)
      Soong YK, Huang SY, Yeh CH, Wang TH, Chang KH, Cheng PJ, Shaw SW
    • Association of MMP-9 Haplotypes and TIMP-1 Polymorphism with Spontaneous Deep Intracerebral Hemorrhage in the Taiwan Population
      PLoS One 10:e0125397.(2015)
      Ho WM, Chen CM, Lee YS, Chang KH, Chen HW, Chen ST, Chen YC
    • Wegener's granulomatosis with nervous system involvement: a hospital-based study
      Eur Neurol 73: 197-204.(2015)
      Huang YH, Ro LS, Lyu RK, Chang HS, Wu YR, Chang KH, Kuo HC
    • Clinical and radiological findings suggesting disorders other than tolosa-hunt syndrome among ophthalmoplegic patients: a retrospective analysis
      Headache 55: 252-64.(2015)
      Hung CH, Chang KH, Chen YL, Wu YM, Lai CL, Chang HS, Lyu RK, Wu YR, Chen CM, Huang CC, Chu CC, Chen CH, Ro LS
    • Genome-wide gene expression profiling of ischemia-reperfusion injury in rat kidney, intestine and skeletal muscle implicate a common involvement of MAPK signaling pathway
      Mol Med Rep 11(5):3786-93 (SCI)(2015)
      Chang NJ, Weng WH, Chang KH, Liu EK, Chuang CK, Luo CC, Lin CH, Wei FC, Pang ST
    • Plasma Inflammatory biomarkers for Huntington's disease patients and mouse model
      Brain Behavior and Immunity 44: 121-127 (SCI)(2015)
      Chang KH, Wu YR, Chen YC, Chen CM
    • Comparison between the cranial magnetic resonance imaging features of neuromyelitis optica spectrum disorder versus multiple sclerosis in Taiwanese patients
      BMC Neurol 14: 218 (SCI)(2015)
      Liao MF, Chang KH*(co-corresponding author), Lyu RK, Huang CC, Chang HS, Wu YR, Chen CM, Chu CC, Kuo HC, Ro LS*
    • Biomarkers for neuromyelitis optica
      Clinica Chimica Acta 440: 64-71 (SCI)(2015)
      Chang KH, Ro LS, Lyu RK, Chen CM
    • Effect of coexistent carpal tunnel abnormality on sensory conduction findings in polyneuropathy
      J Clin Neuromuscul Dis 16:51-8. (EI)(2014)
      Lyu RK, Liao MF, Kuo HC, Chu CC, Chang KH
    • The Potential of Indole and a Synthetic Derivative for PolyQ Aggregation Reduction by Enhancement of the Chaperone and Autophagy Systems
      ACS Chem Neurosci 5:1063-74 (SCI)(2014)
      Lin CH, Wu YR, Kung PJ, Chen WL, Lee LC, Lin TH, Chao CY, Chen CM, Chang KH, Janreddy D, Lee-Chen GJ, Yao CF
    • Clinical correlations of motor and somatosensory evoked potentials in neuromyelitis optica
      PLoS One 9(11):e113631 (SCI)(2014)
      Tsao WC, Lyu RK, Ro LS, Liao MF, Chen CM, Wu YR, Huang CC, Chang HS, Kuo HC, Chu CC, Chang KH*(Corresponding author)
    • Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models
      Drug Des Devel Ther 8:1929-39 (SCI)(2014)
      Kung PJ, Tao YC, Hsu HC, Chen WL, Lin TH, Janreddy D, Yao CF, Chang KH, Lin JY, Su MT, Wu CH, Lee-Chen GJ, Hsieh-Li HM
    • Aqueous extract of Glycyrrhiza inflata inhibits aggregation through upregulating PPARGC1A and NFE2L2-ARE pathways in cell models of spinocerebellar ataxia 3
      Free Radical Biology and Medicine 71: 339-350 (SCI)(2014)
      Chen CM, Weng YT, Chen WL, Lin TH, Chao CY, Lin CH, Chen IC, Lee LC, Lin HY, Wu YR, Chen YC, Chang KH, Tang HY, Cheng ML, Lee-Chen GJ, Lin JY
    • Aqueous extract of Gardenia jasminoides targeting oxidative stress to reduce polyQ aggregation in cell models of spinocerebellar ataxia 3
      Neuropharmacology 81:166-175 (SCI)(2014)
      Chang KH, Chen WL, Wu YR, Lin TH, Wu YC, Chao CY, Lin JY, Lee LC, Chen YC, Lee-Chen GJ, Chen CM
    • Painful ophthalmoplegia with normal cranial imaging
      BMC Neurology 14:7 (SCI)(2014)
      Hung CH#, Chang KH#(Co-first author), Chu CC, Liao MF, Chang HS, Lyu RK, Wu YM, Chen YL, Lai CL, Tseng HJ, Ro LS
    • Motor conduction findings in Fisher syndrome
      European Neurology. 70(5-6):276-280 (SCI)(2013)
      Lyu RK, Chu CC, Kuo HC, Chang KH, Ro LS
    • Genetic variants of LRRK2 in Taiwanese Parkinson's disease
      PLoS One 8(12):e82001. (SCI)(2013)
      Wu YR#, Chang KY#(Co-first author), Chang WT, Hsiao YC, Hsu HC, Chiang PR, Chen YC, Chao CY, Chang YC, Lee BH, Hu FJ, Chen WL, Lee-Chen GJ, Chen CM
    • Rapid progression and brain atrophy in anti-AMPA receptor encephalitis
      Journal of Neuroimmunology 261(1-2):129-33 (SCI)(2013)
      Wei YC, Liu CH, Lin JJ, Lin KJ, Huang KL, Lee TH, Chang YJ, Peng TI, Lin KL, Chang TY, Chang CH, Kuo HC, Chang KH, Cheng MY, Huang CC
    • Sensory Conduction Study in Fisher Syndrome: Patterns of Abnormalities and Their Clinical Correlation
      European Neurology 70: 27-32 (SCI)(2013)
      Lyu RK, Chang KH, Chu CC, Kuo HC, Ro LS
    • Association between PARK16 and Parkinson's disease in the Han-Chinese population: a meta-analysis
      Neurobiology of Aging 34(10):2442.e5-9 (SCI)(2013)
      Chang KH, Chen CM, Chen YC, Lyu RK, Chang HS, Ro LS, Lee-Chen GJ, Wu YR
    • A comparison of benign and inflammatory manifestations of Tolosa-Hunt syndrome
      Cephalalgia 33:842-852 (SCI)(2013)
      Hung CH, Chang KH, Wu YM, Chen YL, Lyu RK, Chang HS, Wu YR, Chen CM, Huang CC, Chu CC, Liao MF, Wai YY, Hsu SP, Ro LS
    • Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3
      Evidence-Based Complementary and Alternative Medicine 2013:471659 (SCI)(2013)
      Chang KH, Chen WL, Lee LC, Lin CH, Kung PJ, Lin TH, Wu YC, Wu YR, Chen YC, Lee-Chen GJ, Chen CM
    • Association between GRN rs5848 polymorphism and Parkinson’s disease in Taiwanese population
      PLoS One 8(1):e54448 (SCI)(2013)
      Chang KH, Chen CM, Chen YC, Hsiao YC, Huang CC, Kuo HC, Hsu HC, Lee-Chen GJ, Wu YR
    • Analyses of haptoglobin level in the cerebrospinal fluid and serum of patients with neuromyelitis optica and multiple sclerosis
      Clinica Chimica Acta 417:26-30 (SCI)(2013)
      Chang KH, Tseng MY, Ro LS, Lyu RK, Tai YH, Chang HS, Wu YR, Huang CC, Hsu WC, Kuo HC, Chu CC, Chen CM
    • Clonal Isolation of an Intermediate Pluripotent State
      Stem Cells 31: 918-927 (SCI) (2013)
      Chang KH*(Corresponding author), Li M
    • Distinct features between longitudinally extensive transverse myelitis presenting with and without anti-Aquaporin 4 antibodies
      Multiple Sclerosis 19: 299-307 (SCI)(2013)
      Chang KH, Lyu RK, Chen CM, Wu YR, Chang HS, Huang CC, Kuo HC, Chu CC, Hsu WC, Ro LS
    • Downregulation of Genes Involved in Metabolism and Oxidative Stress in the Peripheral Leukocytes of Huntington's Disease Patients
      PLoS One 7(9):e46492. (SCI)(2012)
      Chang KH, Chen YC, Wu YR, Lee WF, Chen CM
    • Effect of pre-diabetes on future risk of stroke: meta-analysis
      BMJ 334: e3564. (SCI)(2012)
      Lee M, Saver JL, Hong KS, Song S, Chang KH, Ovbiagele B
    • Features of varicella zoster virus myelitis and dependence on immune status
      J Neurol Sci 318: 19-24. (SCI)(2012)
      Hung CH, Chang KH, Kuo HC, Huang CC, Liao MF, Tsai YT, Ro LS
    • ATXN8-62 G/A promoter polymorphism and risk of Taiwanese Parkinson's disease
      Eur J Neurol 19: 1462-1469(SCI)(2012)
      Chen IC, Wu YR, Yang SJ, Kao SH, Chen YC, Chang KH, Lee CM, Lee-Chen GJ, Chen CM
    • Identification of Gene Networks and Pathways Associated with Guillain-Barre Syndrome
      PLoS ONE 7: e29506 (SCI) (2012)
      Chang KH, Chuang TJ, Lyu RK, Ro LS, Wu YR, Chang HS, Huang CC, Kuo HC, Hsu WC, Chu CC, Chen CM