FMGEMS (Foreign Medical Graduate Examination of Medical Science, compatible with VQE, USMLE), USA
National Board Qualification for Physicians
Advanced glycation end products induce T cell apoptosis: Involvement of oxidative stress, caspase and the mitochondrial pathway. Mech Ageing Dev 2010;131:682-91. Hung LF, Huang KY, Yang DH, Chang DM, Lai JH, Ho LJ.
Biological effects of interleukin-6: Clinical applications in autoimmune diseases and cancers. Biochem Pharmacol 2015 (available on line June 12, 2015). Ho LJ, Luo SF, and Lai JH*.
Up-regulation of galectin-9 induces cell migration in human dendritic cells infected with dengue virus. J Cell Mol Med 2015 (in press). Hsu YL, Wang MY, Ho LJ, Huang CY, and Lai JH*.
Protein kinase C isoforms in atherosclerosis: Pro- or anti-inflammatory? Biochem Pharmacol 2014;88:139-49. Fan HC, Fernandez-Hernando C, Lai JH*.
Differential immunomodulatory effects by Tripterygium wilfordii Hook f-derived refined extract PG27 and its purified component PG490 (triptolide) in human peripheral blood T cells: potential therapeutics for arthritis and possible mechanisms explaining in part Chinese herbal theory "Junn-Chenn-Zuou-SS". J Transl Med 2013;11:294. Ho LJ, Chang WL, Chen A, Chao P, Lai JH*.
Small-molecule inhibitors for autoimmune arthritis: success, failure and the future. Eur J Pharmacol 2015 (in press). Ho LJ, Lai JH*.
Useful biomarkers for assessment of hepatitis C virus infection-associated autoimmune disorders. World J Gastroenterol 2014;20:2962-70. Yang DH, Ho LJ, Lai JH*.
PKCdelta signalling regulates SR-A and CD36 expression and foam cell formation. Cardiovasc Res 2012;95:346-55. Lin CS, Lin FY, Ho LJ, Tsai CS, Cheng SM, Wu WL, Huang CY, Lian CH, Yang SP, Lai JH*.
Antroquinonol differentially modulates T cell activity and reduces interleukin-18 production, but enhances Nrf2 activation, in murine accelerated severe lupus nephritis. Arthritis Rheum 2012;64:232-42. Tsai PY, Ka SM, Chang JM, Lai JH, Dai MS, Jheng HL, Kuo MT, Chen P, Chen A.
A salicylate-based small molecule HS-Cm exhibits immunomodulatory effects and inhibits dipeptidyl peptidase-IV activity in human T cells. Eur J Pharmacol 2014;726C:124-32. Liou JT, Huang HS, Chiang ML, Lin CS, Yang SP, Ho LJ, Lai JH*.
Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes: Potential Therapeutics for Osteoarthritis. PLoS One 2013;8:e82033. Ho LJ, Hung LF, Liu FC, Hou TY, Lin LC, Huang CY, Lai JH*.
Protective roles of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in dengue virus infection of human lung epithelial cells. PLoS One 2013;8:e79518. Hsu YL, Shi SF, Wu WL, Ho LJ, Lai JH*.
Janus kinase/signal transducer and activator of transcription 3 signaling pathway is crucial in chemokine production from hepatocytes infected by dengue virus. Exp Biol Med (Maywood) 2011;236:1156-65. Tsai YT, Chen YH, Chang DM, Chen PC, Lai JH*.
A Benzamide-Linked Small Molecule HS-Cf Inhibits TNF-alpha-Induced Interferon Regulatory Factor-1 in Porcine Chondrocytes: A Potential Disease-Modifying Drug for Osteoarthritis Therapeutics. J Clin Immunol 2011;31:1131-42. Liu FC, Huang HS, Huang CY, Yang R, Chang DM, Lai JH*, Ho LJ.
Magnesium lithospermate B mediates anti-inflammation targeting activator protein-1 and nuclear factor-kappa B signaling pathways in human peripheral T lymphocytes. Int Immunopharmacol 2012;13:354-61. Cheng CC, Yang SP, Lin WS, Ho LJ, Lai JH, Cheng SM, Lin WY.
Immunosuppressive Effects and Mechanisms of Leflunomide in Dengue Virus Infection of Human Dendritic Cells. J Clin Immunol 2011;31: 1065-78. Wu WL, Ho LJ, Chen PC, Tsai YT, Hsu ST, Chang DM, Lai JH*.
Modulation of human T cells signaling transduction by lovastatin. Int J Cardiol 2010;140:24-33. Cheng SM, Lai JH, Yang SP, Tsao TP, Ho LJ, Liou JT, Cheng CC.
The modulatory mechanisms of fenofibrate on human primary T cells. Eur J Pharm Sci 2010;40:316-24. Cheng SM, Chu KM, Lai JH.
A/H1N1 influenza vaccination in patients with systemic lupus erythematosus: safety and immunity. Vaccine 2011;29:444-50. Lu CC, Wang YC, Lai JH, Lee TS, Lin HT, Chang DM.
Phytoestrogen bavachin mediates anti-inflammation targeting Ikappa B kinase-I kappaB alpha-NF-kappaB signaling pathway in chondrocytes in vitro. Eur J Pharmacol 2010;636:181-8. Cheng CC, Chen YH, Chang WL, Yang SP, Chang DM, Lai JH*, Ho LJ.
A spontaneous intercostal artery hemorrhage in systemic lupus erythematosus. Rheumatol Int 2012;32:829-31. Lu CC, Chen CH, Yeh SF, Lai JH, Chang DM.
Remitting seronegative symmetrical synovitis with pitting edema following acute intracranial hemorrhage. Rheumatol Int 2011;31:101-4. Yang DH, Chang DM, Lai JH, Huang GS, Chang WC, Hou TY.
Peripheral arthritis caused by Mycobacterium avium-intracellulare in a patient with ankylosing spondylitis. J Clin Rheumatol 2009;15:323-4. Yang DH, Chang WC, Cheng MF, Lai JH, Chang DM, Chen CH.
Usefulness of erythrocyte-bound C4d as a biomarker to predict disease activity in patients with systemic lupus erythematosus. Rheumatology (Oxford) 2009;48:1083-7. Yang DH, Chang DM, Lai JH, Lin FH, Chen CH.
Significantly higher percentage of circulating CD27(high) plasma cells in systemic lupus erythematosus patients with infection than with disease flare-up. Yonsei Med J 2010;51:924-31. Yang DH, Chang DM, Lai JH, Lin FH, Chen CH.
Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes. Arthritis Res Ther 2010;12:R167. Liu FC, Hung LF, Wu WL, Chang DM, Huang CY, Lai JH*, Ho LJ.
Triggering of DC migration by dengue virus stimulation of COX-2-dependent signaling cascades in vitro highlights the significance of these cascades beyond inflammation. Eur J Immunol 2009;39:3413-22. Wu WL, Ho LJ, Chang DM, Chen CH, Lai JH*.
Etanercept as a rescue agent in patient with adult onset Still's disease complicated with congestive heart failure. Rheumatol Int 2008;29:95-8. Yang DH, Chang DM, Lai JH, Kuo SY, Ho TY, Lin KM, Chen CH.
Suppression of tissue necrosis factor-alpha or hydrogen peroxide-activated primary human T lymphocytes by Ginkgo biloba extract through down-regulation of activator protein-1 signal transduction. Phytomedicine 2008;15:170-6. Tsao TP, Lai JH, Yang SP, Ho LJ, Liou JT, Cheng CC, Cheng SM.
Acupuncture-associated Listeria monocytogenes arthritis in a patient with rheumatoid arthritis. Joint Bone Spine 2008;75:502-3. Tien CH, Huang GS, Chang CC, Chang DM, Lai JH*.
Usefulness of anti-CCP antibodies in patients with hepatitis C virus infection with or without arthritis, rheumatoid factor, or cryoglobulinemia. Clin Rheumatol 2008;27:463-7. Liu FC, Chao YC, Hou TY, Chen HC, Shyu RY, Hsieh TY, Chen CH, Chang DM, Lai JH*.
Differential effects of triptolide and tetrandrine on activation of COX-2, NF-kappaB, and AP-1 and virus production in dengue virus-infected human lung cells. Eur J Pharmacol 2008;589:288-98. Liou JT, Chen ZY, Ho LJ, Yang SP, Chang DM, Liang CC, Lai JH*.
Formation of numerous rice bodies: an unusual finding of adult-onset Still's disease. Clin Rheumatol 2008;27 Suppl 2:S55-7. Lin KM, Lai JH, Chang CC, Lin CK, Chang DM, Chen CH.
Retinoid acid inhibits IL-1-induced iNOS, COX-2 and chemokine production in human chondrocytes. Immunol Invest 2008;37:675-93. Hung LF, Lai JH, Lin LC, Wang SJ, Hou TY, Chang DM, Liang CC, Ho LJ.
Interleukin (IL)-23 p19 expression induced by IL-1beta in human fibroblast-like synoviocytes with rheumatoid arthritis via active nuclear factor-kappaB and AP-1 dependent pathway. Rheumatology (Oxford) 2007;46:1266-73. Liu FL, Chen CH, Chu SJ, Chen JH, Lai JH, Sytwu HK, Chang DM.
Purtscher's-like retinopathy as an initial presentation of adult-onset Still's disease: a case report and review of the literature. Clin Rheumatol 2007;26:1204-6. Liu FC, Chiang SY, Chang DM, Lai JH, Hou TY, Chen CH.
Autoimmune hepatitis with raised alpha-fetoprotein level as the presenting symptoms of systemic lupus erythematosus: a case report. Rheumatol Int 2007;27:489-91. Liu FC, Chang DM, Lai JH, Lin CK, Chen HC, Hou TY, Kuo SY.
Usefulness of human leucocyte antigen-B27 subtypes in predicting ankylosing spondylitis: Taiwan experience. Intern Med J 2007;37:749-52. Hou TY, Chen HC, Chen CH, Chang DM, Liu FC, Lai JH*.
Activin A suppresses interleukin-1-induced matrix metalloproteinase 3 secretion in human chondrosarcoma cells. Rheumatol Int 2007;27:1049-55. Chang DM, Liu SH, Lee HS, Lai JH, Chen CH.
Thymoma and hypogammaglobulinemia (Good's syndrome): a case report. J Microbiol Immunol Infect 2005;38:218-20. Tsai YG, Lai JH, Kuo SY, Chen HC, Chang DM.
Taiwan experience with etanercept in juvenile rheumatoid arthritis. J Microbiol Immunol Infect 2005;38:451-4. Lai JH*.
Sweet's syndrome as an initial presentation in systemic lupus erythematosus: a case report and review of the literature. Lupus 2005;14:399-402. Hou TY, Chang DM, Gao HW, Chen CH, Chen HC, Lai JH*.
Retinoic acid blocks pro-inflammatory cytokine-induced matrix metalloproteinase production by down-regulating JNK-AP-1 signaling in human chondrocytes. Biochem Pharmacol 2005;70:200-8. Ho LJ, Lin LC, Hung LF, Wang SJ, Lee CH, Chang DM, Lai JH*, Tai TY.
Dengue virus type 2 antagonizes IFN-alpha but not IFN-gamma antiviral effect via down-regulating Tyk2-STAT signaling in the human dendritic cell. J Immunol 2005;174:8163-72. Ho LJ, Hung LF, Weng CY, Wu WL, Chou P, Lin YL, Chang DM, Tai TY, Lai JH*.
Systemic lupus erythematosus with simultaneous onset of Kikuchi-Fujimoto's disease complicated with antiphospholipid antibody syndrome: a case report and review of the literature. Rheumatol Int 2005;25:303-6. Chen HC, Lai JH, Huang GS, Gao HW, Chen CH, Kuo SY, Chang DM.
Immunosuppressive iridoids from the fruits of Gardenia jasminoides. J Nat Prod 2005;68:1683-5. Chang WL, Wang HY, Shi LS, Lai JH, Lin HC.
Carvedilol differentially regulates cytokine production from activated human peripheral blood mononuclear cells. Cardiovasc Drugs Ther 2004;18:183-8. Yang SP, Ho LJ, Cheng SM, Hsu YL, Tsao TP, Chang DM, Lai JH*.
An unrecognized cause of oedema in a patient with lupus nephritis: protein losing enteropathy. Nephrol Dial Transplant 2004;19:2149-50. Wu CC, Lin SH, Chu P, Lai JH, Chang DM, Lin YF.
Infection of human dendritic cells by dengue virus activates and primes T cells towards Th0-like phenotype producing both Th1 and Th2 cytokines. Immunol Invest 2004;33:423-37. Ho LJ, Shaio MF, Chang DM, Liao CL, Lai JH*.
Chinese herbs as immunomodulators and potential disease-modifying antirheumatic drugs in autoimmune disorders. Curr Drug Metab 2004;5:181-92. Ho LJ, Lai JH*.
Plant alkaloid tetrandrine downregulates IkappaBalpha kinases-IkappaBalpha-NF-kappaB signaling pathway in human peripheral blood T cell. Br J Pharmacol 2004;143:919-27. Ho LJ, Juan TY, Chao P, Wu WL, Chang DM, Chang SY, Lai JH*.
Irbesartan inhibits human T-lymphocyte activation through downregulation of activator protein-1. Br J Pharmacol 2004;142:933-42. Cheng SM, Yang SP, Ho LJ, Tsao TP, Chang DM, Lai JH*.
Pleural effusion as a manifestation of Lyme disease. J Rheumatol 2004;31:811-3. Chen HC, Shih CM, Lai JH, Chao LL, Kuo SY, Chang DM.
Longitudinal myelitis as an initial manifestation of systemic lupus erythematosus. Am J Med Sci 2004;327:105-8. Chen HC, Lai JH, Juan CJ, Kuo SY, Chen CH, Chang DM.
Neutrophilic panniculitis with myelodysplastic syndromes presenting as pustulosis: case report and review of the literature. Am J Hematol 2004;76:61-5. Chen HC, Kao WY, Chang DM, Gao HW, Lai WY, Lai JH*.
Dual biological functions of an interleukin-1 receptor antagonist-interleukin-10 fusion protein and its suppressive effects on joint inflammation. Immunology 2004;112:643-50. Chang DM, Shyue SK, Liu SH, Chen YT, Yeh CY, Lai JH, Lee HS, Chen A.
Dehydroepiandrosterone suppresses interleukin 10 synthesis in women with systemic lupus erythematosus. Ann Rheum Dis 2004;63:1623-6. Chang DM, Chu SJ, Chen HC, Kuo SY, Lai JH.
The pharmacokinetics of interleukin-1 receptor antagonist in Chinese subjects with rheumatoid arthritis. Pharmacol Res 2004;50:371-6. Chang DM, Chang SY, Yeh MK, Lai JH.
Carvedilol, a new antioxidative beta-blocker, blocks in vitro human peripheral blood T cell activation by downregulating NF-kappaB activity. Cardiovasc Res 2003;59:776-87. Yang SP, Ho LJ, Lin YL, Cheng SM, Tsao TP, Chang DM, Hsu YL, Shih CY, Juan TY, Lai JH*.
Ruptured renal microaneurysms complicated with a retroperitoneal abscess for a patient with systemic lupus erythematosus. Lupus 2003;12:317-20. Tsai YG, Lai JH, Kuo SY, Chen HC, Wan HL, Chang DM.
Relationship between human lymphocyte antigen-B27 and clinical features of psoriatic arthritis. J Microbiol Immunol Infect 2003;36:101-4. Tsai YG, Chang DM, Kuo SY, Wang WM, Chen YC, Lai JH*.
Down-regulation of c-jun N-terminal kinase-activator protein-1 signaling pathway by Ginkgo biloba extract in human peripheral blood T cells. Biochem Pharmacol 2003;66:679-89. Cheng SM, Yang SP, Ho LJ, Tsao TP, Juan TY, Chang DM, Chang SY, Lai JH*.
Carvedilol modulates in-vitro granulocyte-macrophage colony-stimulating factor-induced interleukin-10 production in U937 cells and human monocytes. Immunol Invest 2003;32:43-58. Cheng SM, Yang SP, Ho LJ, Tsao TP, Chang DM, Lai JH*.
Immunosuppressive flavones and lignans from Bupleurum scorzonerifolium. Phytochemistry 2003;64:1375-9. Chang WL, Chiu LW, Lai JH, Lin HC.
Prognostic factors and fetal outcomes of lupus pregnancy in Taiwan. Clin Exp Rheumatol 2003;21:798. Chang DM, Wu YL, Chu SJ, Lai JH.
Immunomodulatory effects and mechanisms of plant alkaloid tetrandrine in autoimmune diseases. Acta Pharmacol Sin 2002;23:1093-101. Lai JH*.
Western and Chinese antirheumatic drug-induced T cell apoptotic DNA damage uses different caspase cascades and is independent of Fas/Fas ligand interaction. J Immunol 2001;166:6914-24. Lai JH*, Ho LJ, Lu KC, Chang DM, Shaio MF, Han SH.
Infection of human dendritic cells by dengue virus causes cell maturation and cytokine production. J Immunol 2001;166:1499-506. Ho LJ, Wang JJ, Shaio MF, Kao CL, Chang DM, Han SW, Lai JH*.
Aspirin differentially regulates endotoxin-induced IL-12 and TNF-alpha production in human dendritic cells. Scand J Rheumatol 2001;30:346-52. Ho LJ, Chang DM, Shiau HY, Chen CH, Hsieh TY, Hsu YL, Wong CS, Lai JH*.
Plant alkaloid tetrandrine and its analog block CD28-costimulated activities of human peripheral blood T cells: potential immunosuppressants in transplantation immunology. Transplantation 1999;68:1383-92. Lai JH*, Ho LJ, Kwan CY, Chang DM, Lee TC.
Plant alkaloid tetrandrine downregulates protein kinase C-dependent signaling pathway in T cells. Eur J Pharmacol 1999;367:389-98. Ho LJ, Chang DM, Lee TC, Chang ML, Lai JH*.
Mechanism of immunosuppression of the antirheumatic herb TWHf in human T cells. J Rheumatol 1999;26:14-24. Ho LJ, Chang DM, Chang ML, Kuo SY, Lai JH*.
Cell surface markers and circulating cytokines in graft versus host disease. Immunol Invest 1999;28:77-86. Chang DM, Wang CJ, Kuo SY, Lai JH.
Effects of anti-rheumatic herbal medicines on cellular adhesion molecules. Ann Rheum Dis 1999;58:366-71. Chang DM, Kuo SY, Lai JH, Chang ML.
RelA is a potent transcriptional activator of the CD28 response element within the interleukin 2 promoter. Mol Cell Biol 1995;15:4260-71. Lai JH, Horvath G, Subleski J, Bruder J, Ghosh P, Tan TH.
Mechanisms of enhanced nuclear translocation of the transcription factors c-Rel and NF-kappa B by CD28 costimulation in human T lymphocytes. Ann N Y Acad Sci 1995;766:220-3. Lai JH, Horvath G, Li Y, Tan TH.
CD28 signaling causes a sustained down-regulation of I kappa B alpha which can be prevented by the immunosuppressant rapamycin. J Biol Chem 1994;269:30077-80. Lai JH, Tan TH.
Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells. Mol Cell Biol 1994;14:7933-42. Bryan RG, Li Y, Lai JH, Van M, Rice NR, Rich RR, Tan TH.
Intercostal arteriovenous fistula due to pleural biopsy. Thorax 1991;46:400. Tariq SM, McConnochie K, Lai JH, Kao SJ, Lee SC, Shen CY.
Intercostal arteriovenous fistula due to pleural biopsy. Thorax 1990;45:976-8. Lai JH, Yan HC, Kao SJ, Lee SC, Shen CY.