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最後更新時間:2017-07-07
網頁負責人:張永達
檢驗醫學 Laboratory Medicine
 
盧章智醫師
語言
國語、英語、閩南語
專長
檢驗醫學、精準醫學檢驗、臨床微生物、實驗室管理、分子診斷學、細菌抗藥機轉研究及分子流行病學
教職
教授
現職
林口長庚紀念醫院檢驗醫學科科主任2011/10~迄今
學歷
印地安那大學醫學院美國病理博士1991 / 8至1995 /6
國防醫學院中華民國病理碩士1984 / 8 至1986 /7
國防醫學院醫學系1975 / 8 至1982 /7
經歷
中國醫藥大學附設醫院檢驗醫學部教授兼部主任
三軍總醫院臨床病理科主任醫師
國防醫學院病理學科教授
學會與認證
台灣臨床病理檢驗醫學會理事長
台灣人類組織抗原學會理事長
台灣微生物學會常務理事
台灣輸血學會常務理
美國病理學稽核員(CAP inspector)
論文及期刊發表
Lin JF, Ge MC, Liu TP, Chang SC, Lu JJ*. 2017. A simple method for rapid microbial identification from positive monomicrobial blood culture bottles through Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry. J Microbiol Immunol Infect. (on-line)
 
Ho CM, Li CY, Ho MW, Lin HC, Peng CT, Lu JJ*. 2017. Concomitant genotyping revealed diverse spreading between MRSA and MSSA in central Taiwan. J Microbiol Immunol Infect. 2014 Oct 8. pii: S1684-1182(14)00166-2. doi: 10.1016/j.jmii.2014.07.010. [Epub ahead of print]PMID:25305708
 
Tsai MH, Hsu JF, Chu SM, Chang PJ, Lai MY, Wu IH, Huang HR, Chiang MC, Fu RH, Lu JJ*. 2017. Clinical and microbiological characteristics, and impact of therapeutic strategies on the outcomes of children with candidemia. Sci Rep. 2017 Apr 24;7(1):1083. doi: 10.1038/s41598-017-01123-6
 
3. Ge MC, Kuo AJ, Liu KL, Wen YH, Chia JH, Chang PY, Lee MH, Wu TL, Chang SC*, Lu JJ*. 2017. Routine identification of bacteria by matrix-assisted laser desorption ionization time-of-flight mass spectrometry: success rate, economic analysis, and clinical outcome. J Microbiol Immunol Infect. 2016 Jun 24. pii: S1684-1182(16)30063-9. doi: 10.1016/j.jmii.2016.06.002. [Epub ahead of print. PMID27426930 (*Equally corresponding author)
 
Lin LC, Shu JC, Chang SC, Ge MC, Liu TP, Chen CW, Lu JJ*. 2017. Association of nucleotide sequence variations in autolysis genes with the inability in biofilm formation of clonal ST 59 methicillin resistant Staphylococcus aureus. Microbial Drug Resistance 2017 Mar 30. doi: 10.1089/mdr.2016.0098. [Epub ahead of print]PMID:28358616
 
Weng SL, Huang KY, Kaunang FJ, Huang CH, Kao HJ, Chang TH, Wang HY, Lu JJ*, Lee TY*. 2017. Investigation and identification of protein carbonylation sites based on position-specific amino acid composition and physicochemical features. BMC Bioinformatics (2017) 18(Suppl 3): 66. doi:10.1186/s12859-017-1472-8
 
Lee IC, Su PH, Chen JY, Hu JM, Lu JJ, Ng YY. 2012. Congenital myotubular myopathy with a novel MTM1 gene mutation in a premature infant presenting with ventilator dependency and intrahepatic cholestasis. J Child Neurol. 2012 Jan;27(1):99-104. Epub 2011 Aug 31
 
Lin CY, Ho CM, Bau DT, Yang SF, Liu SH, Lin PH, Lin TH, Tien N, Shih MC, Lu JJ*. 2012. Evaluation of Breast Cancer Susceptibility loci on 2q35, 3p24, 17q23 and FGFR2 genes in Taiwanese Women with Breast Cancer. Anticancer research. 2012 Feb;32(2):475-482
 
Chao YH, Wu KH, Lu JJ, Shih MC, Peng CT, Chang CW. 2012. Red blood cell alloimmunisation among Chinese patients with β-thalassaemia major in Taiwan. Blood Transfus. 2012 Jun 28:1-4
 
Lin CW, Su IJ, Chang JR, Chen YY, Lu JJ, Dou HY. 2012. Recombinant BCG coexpressing Ag85B, CFP10, and interleukin-12 induces multifunctional Th1 and memory T cells in mice. APMIS. 2012 Jan;120(1):72-82
 
Huang CC, Ho CM, Chen HC, Li CY, Tiien N, Fan HM, Ge MC, Lu JJ*. 2017. Evaluation of double-locus (clfB and spa) sequence typing for studying molecular epidemiology of methicillin-resistant Staphylococcus aureus in Taiwan. J Microbiol Immunol Infect. 2015 Dec 1. pii: S1684-1182(15)00897-X. doi: 10.1016/j.jmii.2015.10.002. [Epub ahead of print]
 
Wang WY, Chiueh TS, Sun JR, Tsao SM, Lu JJ*. 2012. Molecular Typing and Phenotype Characterization of Methicillin-Resistant Staphylococcus aureus Isolates From Blood in Taiwan. PLos One. 2012;7(1):e30394. Epub 2012 Jan 23
 
Ho CM, Ho MW, Lee CY, Tien N, Lu JJ*. 2012. Clonal spreading of methicillin-resistant SCCmec Staphylococcus aureus with specific spa and dru types in central Taiwan. Eur J Clin Microbiol Infect Dis. 2012;31(4):499-504. (SCI)
 
Liao CH, Ko WC, Lu JJ, and Hsueh PR. 2012. Characterizations of Clinical Isolates of Clostridium difficile by Toxin Genotypes and by Susceptibility to 12 Antimicrobial Agents, Including Fidaxomicin (OPT-80) and Rifaximin: A Multicenter Study in Taiwan. Antimicrob Agents Chemother. 2012 Jul;56(7):3943-9. doi: 10.1128/AAC.00191-12. Epub 2012 Apr 16
 
Lu JJ, Tsai FJ; Ho CM; Liu YC; Chen CJ. 2012. Peptide biomarker discovery for rapid identification of methicillin-resistant and vancomycin-intermediate Staphylococcus aureus strains by MALDI-TOF. Anal Chem. 2012 Jul 3;84(13):5685-92
 
Ho CM, Li CY, Ho MW, Lin CY, Lu JJ*. 2012. High rate of qacA/B-positive methicillin-resistant Staphylococcus aureus isolates from chlorhexidine-impregnated catheter-related bloodstream infections.Antimicrob Agents Chemother. 2012:56(11)5693-7
 
Tien N, You BJ, Chang HL, Lin HS, Lee CY, Chung TC, Lu JJ*, Chang CC*. 2012. Comparison of Genospecies and Antimicrobial-Resistant Profiles of the Isolates in the Acinetobacter calcoaceticus - Acinetobacter baumannii Complex from Various Clinical Specimens. Antimicrob Agents Chemother. 2012;56(12):6267-71.(Equally contributed)
 
Weng CY, Ho CM, Dou HY, Ho MW, Lin HS, Chang HL, Li JY, Lin TH, Tien N, Lu JJ*. 2013. Molecular typing of Mycobacterium tuberculosis isolated from patients with TB spondylitis. J Microbiol Immunol Infect. 46(1):19 – 23
 
Hung KH, Yan JJ, Lu JJ, Chen HM, Wu JJ. 2013. Characterization of the modified Hodge test-positive isolates of Enterobacteriaceae in Taiwan. J Microbiol Immunol Infect. 46(1):35 – 40
 
Lin HH, Liu YF, Tien N, Ho CM, Hsu LN, Lu JJ*. 2013. Evaluation of the blood volume effect on the diagnosis of bacteremia in automated blood culture systems. J Microbiol Immunol Infect. 46(1):48 – 52
 
Lee IC, Lu JJ, Lee NC, Su PH. 2013. Mitochondrial depletion causes neonatal-onset Leigh Syndrome myopathy and renal tubulopathy. J Child Neurol. 28(3):404-8
 
Ho CM, Ho MW, Chi CY, Lin CD, Lin CW, Tseng SP, Teng LJ, Chang HC, Chang HL, Chang YF, Lin HH, Tien N, Lu JJ*, and Lai CH*. 2013. Repeated colonization of multidrug–resistant Acinetobacter calcoaceticus-Acinetobacter baumannii complex and changes in antimicrobial susceptibilities in surgical intensive care units. Surg Infect (Larchmt). 2013 Feb;14(1):43-8. (Equally contributed)
 
Lin HC, Lin HY, Su BH, Ho MW, Ho CM, Lee CY, Lin MH, Hsieh HY, Lin HC, Li TC, Lu JJ*. 2013. Reporting an Outbreak of Candida pelliculosa Fungemia in a Neonatal Intensive Care Unit. J Microbiol Immunol Infect. 46: 456-62
 
Chiueh TS, Lee SY, Tang SH, Lu JJ, Sun JR. 2013. Predominance of Enterobacteriaceae Isolates in Early Positive Anaerobic Blood Culture Bottles in BacT/Alert System. J Clin Lab Anal. J Clin Lab Anal. 2013 Mar;27(2):113-20
 
Peng CT, Liu SC, Peng YC, Lin TH, Wang SJ, Le CY, Shih MC, Tien N, Lu JJ, Lin CY. 2013. Distribution of thalassemias and associated hemoglobinopathies identified by prenatal diagnosis in Taiwan. Blood Cells Mol Dis. 2013 Oct;51(3):138-41
 
Chen CJ, Lin MH, Shu JC, Lu JJ*. 2014. Reduced susceptibility to vancomycin in isogenic Staphylococcus aureus strains of sequence type 59: Tracking evolution and identifying mutations by whole-genome sequencing. J Antimicrob Chemother. 2014 Feb;69(2):349-54
 
Tsai CT, Chi CY, Ho CM, Lin PC, Chou CH, Wang JH, Wang JH, Lin HC, Tien N, Lin KH, Ho MW*, Lu JJ*. 2014. Correlation of virulence genes to clinical manifestations and outcome in patients with Streptococcus dysgalactiae subspecies equisimilis bacteremia. J Microbiol Immunol Infect. 47: 462-8
 
Kuo AJ, Su LH, Shu JC, Wang JT, Wang JH, Fung CP, Chia JH, Lu JJ, Wu TL. 2014. National Surveillance on Vancomycin-Resistant Enterococcus faecium in Taiwan: Emergence and Widespread of ST414 and a Tn1546-like Element with Simultaneous Insertion of IS1251-like and IS1678. PLoS One. 2014 Dec 30;9(12):e115555
 
Lin CS, Su CC, Hsieh SC, Lu CC, Wu TL, Jia JH, Wu TS, Han CC, Tsai WC, Lu JJ*, Lai HC*. 2015. Rapid identification of Mycobacterium avium clinical isolates by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry. J Microbiol Immunol Infect. 48: 205-12
 
Su CC, Lai CL, Tsao SM, Lin MN, Hsieh TC, Lu JJ, Chu TY. 2015. High prevalence of human herpesvirus type 8 infection in patients with pulmonary tuberculosis in Taiwan. Clin Microbiol Infect. 2015 Mar;21(3):266.e5-7. doi: 10.1016/j.cmi.2014.10.015. Epub 2014 Oct 29.PMID:25658539
 
Chang SC, Liu TP, Chen CJ, Lin LC, Lu JJ*. 2015. An optimized δ-hemolysis assay for detection of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates. Diagn Microbiol Infect Dis. 2015: 81(4):246-50
 
26. Cheng CW, Liu TP, Yeh CF, Chang SCh, Lee MH, Lu JJ*. 2015. Persistence of a endemic clone of methicillin-resistant Staphylococcus lugdunensis sequence type 6 at a tertiary medical center in northern Taiwan through forty months. Int J Infect Dis. 2015 Jun 4;36:72-7
 
Ho CM, Ho MW, Li CY, Lu JJ*. 2015. Fine typing of methicillin-resistant Staphylococcus aureus isolates using direct repeat unit and staphylococcal interspersed repeat unit typing methods. J Microbiol Immunol Infect. 2015 Aug;48(4):370-5
 
Lin JF, Cheng CW, Kuo AJ, Liu TP, Yang CC, Huang CT, Lee MH, Lu JJ*. 2015. Clinical experience and microbiologic characteristics of invasive Staphylococcus lugdunensis infection in a tertiary center in northern Taiwan. J Microbiol Immunol Infect. 2015 Aug;48(4):406-12
 
Tsai MH, Wang SH, Hsu JF, Lin LC, Chu SM, Huang HR, Chiang MC, Fu RH, Lu JJ* and Huang YC*. 2015. Clinical and molecular characteristics of bloodstream infections caused by Candida albicans in children from 2003 to 2011. Clin Microbiol Infect. 2015 Jul 3. pii: S1198-743X(15)00683-7. doi: 10.1016/j.cmi.2015.06.024. [Epub ahead of print]PMID:26148466 (*equally contributed)
 
Wang SH, Shen M, Lin HC, Sun PL, Lo HJ, Lu JJ*. 2015. Molecular epidemiology of invasive Candida albicans at a tertiary hospital in northern Taiwan from 2003 to 2011. Med Mycol. 2015 Nov 1;53(8):828-36
 
Yeh CF, Liu TP, Cheng CW, Chang SC, Lee MH, Lu JJ*. 2015. Molecular characteristics of disease-causing and commensal Staphylococcus lugdunensis isolates from 2003 to 2013 at a tertiary hospital in Taiwan. PLoS One. 2015 Aug 6;10(8):e0134859. doi: 10.1371/journal.pone.0134859.eCollection 2015.PMID:26248332
 
Wen YH, Chang PY, Hsu CM, Wang HY, Chiu CT, Lu JJ*. 2015. Cancer screening through a multi-analyte serum biomarker panel during health check-up examinations: results from a 12-year Experience. Clin Chim Acta. 2015 Oct 23;450:273-6
 
Hu HC, Kao KC, Chiu LC, Chang CH, Hung CY, Liu TP, Lin LC, Huang CC, Yang CT, Lu JJ*. 2015. Clinical outcomes and molecular typing of heterogenous vancomycin-intermediate Staphylococcus aureus bacteremia in patients in intensive care units. BMC Infect Dis 2015 Oct 23;15(1):444. doi: 10.1186/s12879-015-1215-2
 
Huang YT, Ko WC, Chan YJ, Lu JJ, Tsai HY, Liao CH, Sheng WH, Teng LJ, Hsueh PR. 2015. Disease Burden of Invasive Listeriosis and Molecular Characterization of Clinical Isolates in Taiwan, 2000-2013. PLoS One. 2015 Nov 10;10(11):e0141241. doi: 10.1371/journal.pone.0141241. eCollection 2015
 
17. Chang PY, Chen JS, Chang NC, Chang SC, Wang MC, Tsai SH, Wen YH, Tsai WS, Chan EC, Lu JJ*. 2016. NRAS germline variant G138R and multiple rare somatic mutations on APC in colorectal cancer patients in Taiwan by next generation sequencing. Oncotarget. 2016;7: 37566-80. Apr 21. doi: 10.18632/oncotarget.8885. [Epub ahead of print]
 
Lin HC, Chen CJ, Chiang KH, Yen TY, Ho CM, Hwang KP, Su BH, Lin HC, Li TC, Lu JJ.*. 2016. Clonal dissemination of invasive and colonizing clonal complex 1 of serotype VI group B Streptococcus in central Taiwan. J Microbiol Immunol Infect. 2016 Dec;49(6):902-909
 
Yen TY, Sung YJ, Lin HC, Chiang KH, Chen HC, Peng CT, Lu JJ*. 2016. Emerging of oxacillin-Resistant Staphylococcus lugdunensis carrying SCCmec type V in central Taiwan. J Microbiol Immunol Infect. 2016 Dec;49(6):885-891
 
Sun PL, Lin HC, Hsiao PF, Lu JJ*. 2016. Application of restriction fragment length polymorphism (RFLP) and high resolution melting (HRM) analysis of beta-tubulin gene for species and strains differentiation in Trichophyton mentagrophytes species complex. J Dermatol Sci. 2016 May 24. pii: S0923-1811(16)30100-1. doi: 10.1016/j.jdermsci. 2016.05.013. [Epub ahead of print]
 
Yeh CF, Chang SC, Cheng CW, Lin JF, Liu TP, Lu JJ*. 2016. Clinical features, outcome and molecular characteristics of community- and healthcare-associated Staphylococcus lugdunensis infections. J Clin Microbiol. 2016 Aug;54(8):2051-7
 
Wang HY, Hsieh CH, Wen CN, Wen YH, Chen CH*, Lu JJ*. 2016. Cancers Screening in an Asymptomatic Population by Using Multiple Tumour Markers. PLoS One. 2016 Jun 29;11(6):e0158285. doi: 10.1371/journal.pone.0158285. eCollection 2016
 
Peng HH, Chang NC, Chen KT, Lu JJ, Chang PY, Chang SC, Wu-Chou YH, Chou YT, Phang W, Cheng PJ. 2016. Nonsynonymous variants in MYH9 and ABCA4 are the most frequent risk loci associated with nonsyndromic orofacial cleft in Taiwanese population. BMC Med Genet. 2016 Aug 15;17(1):59. doi: 10.1186/s12881-016-0322-2. PMID27527345
 
Ho CM, Li CY, Ho MW, Lin HC, Lin LC, Lu JJ*. 2016. Methicillin-resistant Staphylococcus aureus isolates with oxacillin minimal inhibitory concentration ? 2 μg/ml usually belong to SCCmec type V with spa type t437 or t1081 in Taiwan. Diagn Microbiol Infec Dis 2016 Dec;86(4):405-411
 
Lin CS, Tsai YH, Chang CJ, Tseng SF, Wu TR, Lu CC, Wu TS, Lu JJ, Horng JT, Martel J, Ojcius DM, Lai HC, Young JD. An iron detection system determines bacterial swarming initiation and biofilm formation. 2016. Sci Rep. 2016 Nov 15;6:36747. doi: 10.1038/srep36747.PMID:27845335
 
Lai HC, Horng YT, Yeh PF, Wang JY, Shu CC, Lu CC, Lu JJ, Lee JJ, Soo PC. 2016. The assessment of host and bacterial proteins in sputum from active pulmonary tuberculosis. J Microbiol. 2016 Nov;54(11):761-767