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醫療團隊

專業的醫護人員，提供最佳的醫療服務

醫師介紹

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陳品元醫師

陳品元醫師

喚醒腦瘤手術 微創匙孔腦部手術 微創脊椎手術 頸椎人工椎間盤置換
  • 國語,英語
  • 教授
醫師網路掛號
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醫師資歷
  • 現職
    • 基隆長庚外科部部長
    • 長庚大學醫學系教授
    • 台灣神經腫瘤學學會理事長
  • 學歷
    • 長庚大學 臨床醫學研究所 博士
    • 長庚大學醫學系 學士
  • 經歷
    • 2023/7 迄今 基隆長庚紀念醫院外科部部長
    • 2019/7 迄今 基隆長庚紀念醫院 腦神經外科 教授級主治醫師
    • 2021/7至2024/6 基隆長庚紀念醫院 醫學研究發展部 主任
    • 2017/7至2023/6 基隆長庚紀念醫院 腦神經外科主任
    • 2016/7至2019/6 林口長庚紀念醫院 腦神經外科 副教授級主治醫師
    • 2012/7至2016/6 林口長庚紀念醫院 腦神經外科 助理教授級主治醫師
    • 2010/9至2012/9 舊金山加大腦瘤研究中心研究員
  • 學會與認證
    • 台灣神經腫瘤學學會理事長
    • 台灣神經創傷暨重症學會監事
    • 台灣中青年神經外科醫學會理事
    • 台灣外科醫學會理事
    • 基隆市醫師公會理事
    • 台灣神經外科醫學會理事
    • 2023 未來科技獎
    • 2023 第十九屆國家新創獎學研新創獎
    • 2021 第十八屆國家新創獎臨床新創獎
    • 2019 第十六屆國家新創獎臨床新創獎
    • 2018 長庚大學傑出校友
    • 2017 基隆長庚紀念醫院長庚研究獎
    • 2015 第十二屆國家新創獎學研新創獎
    • 2015 台灣神經外科醫學會第十二屆第一次會員大會暨學術研討會之腦瘤專題競賽「特等獎」
    • 2015 林口長庚紀念醫院優秀教師獎
    • 2011 林口長庚外科部傑出研究獎
  • 論文及期刊發表
    • Acrolein induces exosomal miR-30a-5p/NCAM1 axis promoting glioma progression.
      Molecular Cancer Therapeutics. 2025 Jun 13.
      Tsai HC, Liu PY, Tong ZJ, Wu CY, Lin YR, Wei KC, Huang CY, Chen KT, Lin YJ, Chen PY*
    • Tumor-Associated Microglia Secrete Extracellular ATP to Support Glioblastoma Progression.
      Cancer Research. 2024 Dec 2;84(23):4017-4030.
      Caren Wu YJ, Chen YU, Lin YJ, Wei KC, Chang KY, Feng LY, Chen KT, Li G, Alexander Ren L, Nitta RT, Wu JY, Cho KB, Pant A, Choi J, Crystal L M, Lily H Kim 2, Wu AC, Chuang JY, Huang CY, Christopher M J, Chen PY*
    • Psychometric properties and structural validity of traditional Chinese version of the Richards-Campbell Sleep Questionnaire in intensive care unit patients without physical restraint.
      Aust Crit Care. 2024 Jul;37(4):558-562.
      Chen PY, Kuo TM, Chen SH, Huang HC, Chen TJ, Wang TH, Wang HL, Chiu HY
    • Psychometric properties and factor structure of the traditional Chinese version of the Community Integration Questionnaire-Revised in traumatic brain injury survivors.
      International Journal of Rehabilitation Research. 2024 Jun 1;47(2):129-134.
      Chen PY, Wei L, Su YK, Lin JH, Jang JW, Hou WH, Hsu LF, Chiu HY
    • Life After Traumatic Brain Injury: Effects on the Lifestyle and Quality of Life of Community-Dwelling Patients.
      Neurotrauma Reports. 2024 Mar 1;5(1):159-171.
      Wei YC, Chen CK, Chemin Lin, Shyu YC, Chen PY
    • Augmented Reality Surgical Navigation System Integrated with Deep Learning.
      Bioengineering (Basel). 2023 May 20;10(5):617.
      Chiou SY, Liu LS, Lee CW, Kim DH, Al-Masni MA, Liu HL, Wei KC, Yan JL, Chen PY*
    • Effects of Neurofeedback on Cognitive Function, Productive Activity, and Quality of Life in Patients With Traumatic Brain Injury: A Randomized Controlled Trial.
      Neurorehabil Neural Repair. 2023 May;37(5):277-287.
      Chen PY, Su IC, Shih CY, Liu YC, Su YK, Wei L, Luh HT, Huang HC, Tsai PS, Fan YC, Chiu HY
    • Augmented Reality Surgical Navigation System for External Ventricular Drain.
      Healthcare (Basel). 2022 Sep 21;10(10):1815.
      Chiou SY, Zhang ZY, Liu HL, Yan JL, Wei KC, Chen PY*
    • A manzamine-derived compound as a potential therapeutic agent for glioma by inducing apoptosis and cell cycle arrest.
      American Journal of Cancer Research. 2022 Apr 15;12(4):1740-1751.
      Lin YJ, Huang CY, Shen YC, Wei KC, Chuang CC, Hsu PW, Huang YC, Hwang TL, Chen PY*
    • Comparative efficacy of prophylactic anticonvulsant drugs following traumatic brain injury: A systematic review and network meta-analysis of randomized controlled trials.
      PLoS One 2022 Mar 31;17(3):e0265932.
      Wang BC, Chiu HY, Luh HT, Lin CJ, Hsieh SH, Chen TJ, Wu CR, Chen PY*
    • A Robust, Fully Automatic Detection Method and Calculation Technique of Midline Shift in Intracranial Hemorrhage and Its Clinical Application.
      Diagnostics (Basel) 2022 Mar 11;12(3):693.
      Yan JL, Chen YL, Chen MY, Chen BA, Chang JX, Kao CC, Hsieh MC, Peng YT, Huang KC, Chen PY*
    • HDAC6 involves in regulating the lncRNA-microRNA-mRNA network to promote the proliferation of glioblastoma cells.
      Journal of Experimental & Clinical Cancer Research 2022 Feb 2;41(1):47.
      Wu AC, Yang WB, Chang KY, Lee JS, Liou JP, Su RY, Cheng SM, Hwang DY, Kikkawa U, Hsu TI, Wang CY, Chang WC, Chen PY*, Chuang JY*
    • Mental fatigue mediates the relationship between cognitive functions and return to productive activity following traumatic brain injury: a mediation analysis.
      Brain Injury 2022 Jan 2;36(1):32-38.
      Chen PY, Hsieh SH, Lin CK, Wei L, Su YK, Tsai PS, Chiu HY
    • Using cortical function mapping by awake craniotomy dealing with the patient with recurrent glioma in the eloquent cortex.
      Biomedical Journal. 2021 Dec;44(6 Suppl 1):S48-S53.
      Li YC, Chiu HY, Wei KC, Lin YJ, Chen KT, Hsu PW, Huang YC, Chen PY
    • Prevalence of sleep disturbances and their effects on quality of life in adults with untreated pituitary tumor and meningioma.
      J Neurooncol. 2021 Sep;154(2):179-186.
      Lin MR%, Chen PY%, Wang HC, Lin PC, Lee HC, Chiu HY
    • Endoscopic transsphenoidal surgery for resection of pituitary macroadenoma: A retrospective study.
      PLoS One 2021 Aug 6;16(8):e0255599.
      Yan JL, Chang CN, Chen PY*
    • A Neural Network Approach to Identify Glioblastoma Progression Phenotype from Multimodal MRI.
      Cancers (Basel) 2021 Apr 21;13(9):2006.
      Yan JL, Toh CH, Ko L, Wei KC, Chen PY*
    • Editorial: advances in neuro-oncology and clinical treatment-from ASNO 2019.
      J Neurooncol. 2020 Feb;146(3):397-398.
      Chen PY, Wei KC.
    • CCL5 of glioma-associated microglia/macrophages regulates glioma migration and invasion via calcium-dependent matrix metalloproteinase-2.
      Neuro-Oncology 2020 Feb 20;22(2):253-266.
      Wu CY, Chen CH, Lin CY, Feng LY, Lin YC, Wei KC, Huang CY, Fang JY*, Chen PY*
    • Functional Change of Effector Tumor-Infiltrating CCR5+CD38+HLA-DR+CD8+ T Cells in Glioma Microenvironment.
      Frontiers in Immunology 2019 Oct 9;10:2395.
      Chen PY%, Wu CY%, Fang JH, Chen HC, Feng LY, Huang CY, Wei KC, Fang JY, Lin CY.
    • Awake craniotomies for epileptic gliomas: intraoperative and postoperative seizure control and prognostic factors.
      J Neurooncol. 2019 May;142(3):577-586.
      Wang YC, Lee CC, Takami H, Shen S, Chen KT, Wei KC, Wu MH, Worrell G, Chen PY*
    • Convection-Enhanced Delivery of a Virus-Like Nanotherapeutic Agent with Dual-Modal Imaging for Besiegement and Eradication of Brain Tumors.
      Theranostics. 2019 Feb 28;9(6):1752-1763.
      Pang HH%, Chen PY%, Wei KC, Huang CW, Shiue YL, Huang CY, Yang HW
    • Intraoperative linguistic performance during awake brain surgery predicts postoperative linguistic deficits.
      Journal of Neuro-Oncology. 2018 Aug;139(1):215-223.
      Chang WH, Pei YC, Wei KC, Chao YP, Chen MH, Yeh HA, Jaw FS, Chen PY*
    • Anterior Skull Base Tumor Resection by Transciliary Supraorbital Keyhole Craniotomy: A Single Institutional Experience.
      World Neurosurg. 2018 Mar:111:e863-e870.
      Lin YJ, Chen KT, Lee CC, Toh CH, Wu TE, Huang YC, Hsu PW, Lu YJ, Chuang CC, Chen PY*, Wei KC.
    • Biomimetic brain tumor niche regulates glioblastoma cells towards a cancer stem cell phenotype.
      Journal of Neuro-Oncology. 2018 May;137(3):511-522.
      Liu YC, Lee IC, Chen PY*
    • Controlled Release of Liposome-Encapsulated Temozolomide for Brain Tumor Treatment by Convection-Enhanced Delivery.
      Journal of Drug Targeting. 2018 Apr;26(4):325-332.
      Lin CY, Li RJ, Huang CY, Wei KC*, Chen PY*
    • Seizures in surgically resected atypical and malignant meningiomas: Long-term outcome analysis.
      Epilepsy Research. 2018 Feb;140:82-89.
      Wang YC, Chuang CC, Tu PH, Wei KC, Wu CT, Lee CC, Liu ZH, Chen PY*
    • Trends in the incidence of primary malignant brain tumors in Taiwan and correlation with comorbidities: A population-based study.
      Clinical Neurology and Neurosurgery. 2017 Aug; 159:72-82.
      Lin YJ, Chiu HY, Chiou MJ, Huang YC, Wei KC, Kuo CF, Hsu JT, Chen PY*
    • Rapid In Situ MRI Traceable Gel-forming Dual-drug Delivery for Synergistic Therapy of Brain Tumor.
      Theranostics. 2017 Jun 25;7(9):2524-2536.
      Lin FW%, Chen PY%, Wei KC, Huang CY, Wang CK, Yang HW
    • Drug-carrying microbubbles as a theranostic tool in convection-enhanced delivery for brain tumor therapy.
      Oncotarget. 2017,March 15 DOI: 10.18632/oncotarget.16218.
      Chen PY, Yeh CK, Hsu PH, Lin CY, Huang CY, Wei KC, Liu HL.
    • Diagnostic accuracy of the Berlin questionnaire, STOP-BANG, STOP, and Epworth sleepiness scale in detecting obstructive sleep apnea: A bivariate meta-analysis.
      Sleep Med Rev. 2016 Nov 5. pii: S1087-0792(16)30127-7. doi: 10.1016/j.smrv.2016.10.004.
      Chiu HY, Chen PY, Chuang LP, Chen NH, Tu YK, Hsieh YJ, Wang YC, Guilleminault C.
    • Long Term Surgical Outcome and Prognostic Factors of Atypical and Malignant Meningiomas.
      Scientific Reports. 2016 Oct, 6:35743.
      Wang YC, Chuang CC, Wei KC, Chang CN, Lee ST, Wu CT, Hsu YH, Lin TK, Hsu PW, Huang YC, Tseng CK, Wang CC, Chen YL, Chen PY*
    • Differences Between Men and Women Aged 65 and Older in the Relationship Between Self-Reported Sleep and Cognitive Impairment: A Nationwide Survey in Taiwan.
      Journal of the American Geriatrics Society. 2016 Oct;64(10):2051-2058.
      Chiu HY, Lai FC, Chen PY*, Tsai PS*
    • Focused Ultrasound Enhances Central Nervous System Delivery of Bevacizumab for Malignant Glioma Treatment.
      Radiology. 2016 Oct; 281(1): 99-108.
      Liu HL, Hsu PH, Lin CY, Huang CW, Chai WY, Chu PC, Huang CY, Chen PY, Yang LY, Kuo JS, Wei KC*
    • The Outcome Predictors of Malignant Large Infarction and the Functional Outcome of Survivors Following Decompressive Craniectomy.
      World Neurosurgery. 2016 Sep;93:133-8.
      Lin TK, Chen SM, Huang YC, Chen PY, Chen MC, Tsai HC, Lee TH, Chen KT, Lee MH, Yang JT, Huang KL.
    • Daytime sleepiness is independently associated with falls in older adults with dementia.
      Geriatrics & Gerontology International 2016 Jul, 16(7):850-855.
      Chen PY, Chiu HT, Chiu HY*
    • Effects of Intravenous and Oral Magnesium on Reducing Migraine: A Meta-analysis of Randomized Controlled Trials.
      Pain Physician 2016 Jan, 19(1):E97-E112.
      Chiu HY, Yeh TH, Huang YC, Chen PY*
    • Neural immune modulation and immunotherapy assisted by focused ultrasound induced blood-brain barrier opening.
      Human Vaccines & Immunotherapeutics 2015 Nov, 11(11):2682-87.
      Chen PY, Wei KC, Liu HL*
    • Reminiscence therapy improves cognitive functions and reduces depressive symptoms in elderly people with dementia: a meta-analysis of randomized controlled trials.
      Journal of the American Medical Directors Association 2015 Sep, 16(12):1087-94.
      Huang HC, Chen YT, Chen PY, Huey-Lan Hu S, Liu F, Kuo YL, Chiu HY*
    • Trajectories of sleep and its predictors in the first year following traumatic brain injury.
      Journal of Head Trauma Rehabilitation 2015 Jul-Aug, 30(4):E50-5.
      Chen PY, Tsai PS, Chen NH, Chaung LP, Lee CC, Chen CC, Chiu HT, Lu YJ, Wei KC, Chiu HY*
    • Corpus callosum involvement and postoperative outcomes of patients with gliomas.
      Journal of Neuro-Oncology 2015 Jun, 124(2):207-14.
      Chen KT, Wu TW, Chuang CC, Hsu YH, Hsu PW, Huang YC, Lin TK, Chang CN, Lee ST, Wu CT, Tseng CK, Wang CC, Pai PC, Wei KC, Chen PY*
    • A programmable high-voltage compliance neural stimulator for deep brain stimulation in vivo.
      Sensors 2015 May, 15(6):12700-19.
      Gong CS, Lai HY*, Huang SH, Lo YC, Lee N, Chen PY, Tu PH, Yang CY, Lin JC, Chen YY*
    • Walking improves sleep in individuals with cancer: a meta-analysis of randomized, controlled trials.
      Oncology Nursing Forum 2015 Mar, 42(2):E54-62.
      Chiu HY, Huang HC, Chen PY, Hou WH, Tsai PS*
    • Focused ultrasound-induced blood-brain barrier opening to enhance interleukin-12 delivery for brain tumor immunotherapy: a preclinical feasibility study.
      Journal of Translational Medicine 2015 Mar, 13:93.
      Chen PY, Hsieh HY, Huang CY, Lin CY, Wei KC, Liu HL*
    • Skull base atypical meningioma: long term surgical outcome and prognostic factors.
      Clinical Neurology and Neurosurgery 2015 Jan, 128:112-6.
      Wang YC, Chuang CC, Wei KC, Hsu YH, Hsu PW, Lee ST, Wu CT, Tseng CK, Wang CC, Chen YL, Jung SM, Chen PY*
    • Pharmacodynamic and therapeutic investigation of focused ultrasound-induced blood-brain barrier opening for enhanced temozolomide delivery in glioma treatment.
      PLoS One 2014 Dec, 9(12):e114311.
      Liu HL*, Huang CY, Chen JY, Wang HY, Chen PY, Wei KC*
    • Transglutaminase 2 expression is increased as a function of malignancy grade and negatively regulates cell growth in meningioma.
      PLoS One 2014 Sep, 9(9):e108228.
      Huang YC, Wei KC, Chang CN, Chen PY, Hsu PW, Chen CP, Lu CS, Wang HL, Gutmann DH, Yeh TH*
    • Gadolinium-functionalized nanographene oxide for combined drug and microRNA delivery and magnetic resonance imaging.
      Biomaterials 2014 Aug, 35(24):6534-42.
      Yang HW, Huang CY, Lin CW, Liu HL, Huang CW, Liao SS, Chen PY, Lu YJ, Wei KC*, Ma CC*
    • Design and experimental evaluation of a 256-channel dual-frequency ultrasound phased-array system for transcranial blood-brain barrier opening and brain drug delivery.
      IEEE Transactions on Biomedical Engineering 2014 Apr, 61(4):1350-60.
      Liu HL*, Jan CK, Chu PC, Hong JC, Lee PY, Hsu JD, Lin CC, Huang CY, Chen PY, Wei KC*
    • The association between use of dietary supplements and headache or migraine complaints.
      Headache 2014 Feb, 54(2):355-63.
      Chiu HY, Tsai PS, Lee CC, Liu YT, Huang HC, Chen PY*
    • Trajectories of sleep changes during the acute phase of traumatic brain injury: a 7-day actigraphy study.
      Journal of the Formosan Medical Association 2013 Sep, 112(9):545-53.
      Chiu HY, Chen PY, Chen NH, Chuang LP, Tsai PS*
    • EGRF conjugated PEGylated nanographene oxide for targeted chemotherapy and photothermal therapy.
      Biomaterials 2013 Sep, 34(29):7204-14.
      Yang HW, Lu YJ, Lin KJ, Hsu SC, Huang CY, She SH, Liu HL, Lin CW, Xiao MC, Wey SP, Chen PY, Yen TC, Wei KC*, Ma CC*
    • Non-invasive synergistic treatment of brain tumors by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide.
      Advanced Materials 2013 Jul, 25(26):3605-11.
      Yang HW, Hua MY, Hwang TL, Lin KJ, Huang CY, Tsai RY, Ma CC, Hsu PH, Wey SP, Hsu PW, Chen PY, Huang YC, Lu YJ, Yen TC, Feng LY, Lin CW, Liu HL*, Wei KC*
    • Enhanced drug delivery system for brain tumor treatment.
      台灣博碩士論文知識加值系統(NDLTD) 2013 Jul.
      Chen PY, Liu HL*
    • MicroRNA-495 inhibits proliferation of glioblastoma multiforme cells by downregulating cyclin-dependent kinase 6.
      World Journal of Surgical Oncology 2013 Apr, 11:87.
      Chen SM, Chen HC, Chen SJ, Huang CY, Chen PY, Wu TW, Feng LY, Tsai HC, Lui TN, Hsueh C, Wei KC*
    • Focused ultrasound-induced blood-brain barrier opening to enhance temozolomide delivery for glioblastoma treatment: a preclinical study.
      PLoS One 2013 Mar, 8(3):e58995.
      Wei KC*, Chu PC, Wang HY, Huang CY, Chen PY, Tsai HC, Lu YJ, Lee PY, Tseng IC, Feng LY, Hsu PW, Yen TC, Liu HL*
    • Comparing routes of delivery for nanoliposomal irinotecan shows superior anti-tumor activity of local administration in treating intracranial glioblastoma xenografts.
      Neuro-Oncology 2013 Feb, 15(2):189-97.
      Chen PY, Ozawa T, Drummond DC, Kalra A, Fitzgerald JB, Kirpotin DB, Wei KC, Butowski N, Prados MD, BergerMS, Forsayeth JR, Bankiewicz K, James CD*
    • Neuronavigation-guided focused ultrasound-induced blood-brain barrier opening: a preliminary study in swine.
      American Journal of Neuroradiology 2013 Jan, 34(1):115-20.
      Wei KC, Tsai HC, Lu YJ, Yang HW, Hua MY, Wu MF, Chen PY, Huang CY, Yen TC, Liu HL*