Chia-Wei Liou (劉嘉為)

Sex: Male.

Birth Date: 1957-3-20

Education: September 1977--June 1984, TaipeiMedicalUniversity

Academic Appointment:

Teaching Position: 部定助理教授：助理字第9620號，長庚大學。(2002/11/1)

Employment Record:

July 1984 -- June 1987: Resident, Department of Neurology, CGMH at Taipei.

July 1987 -- June 1988: Chief Resident, Neurology, CGMH at Taipei.

July 1988 -- June 1989: Clinical Fellow, Neurology, CGMH at Taipei.

July 1989 -- June 1999: Attending Staff, Neurology, CGMH at Kaohsiung.

July 1999 -- Chief, Department of Neurology, CGMH at Kaohsiung.

July 2001 -- Chief, First Department of Neurology, CGMH at Kaohsiung.

(CGMH: ChangGungMemorialHospital)

Professional Affiliations:

1. The Formosan Medical Association.

2. The Taiwan Neurologic Society.

3. The Taiwan Stroke Society.

4. The Society of Ultrasound in Medicine of the Republic of China.

5. AmericanAcademy of Neurology.

6. The European Federation of Neurological Societies.

Professional Activities:

1. Executive members of the Taiwan Stroke Society since 1997.

2. Tutorship of Neurosonology in SUMRC

3.衛生署新感染症症候群醫療諮詢委員, 2002/8/1始

4. Editor of Acta Neurological Taiwanica, 2003 始

Research Project:

• 國科會研究計劃NMRP 407, 1998-1999, 王珮文劉嘉為王新台, Insulin resistance and cerebrovascular atherosclerosis, 胰島素抗性與腦血管動脈硬化(NSC-88-2314-B-182-110)
• 廠商贊助研究計劃SMRP, 1999, 張谷州劉嘉為, Nadroparine in moderate acute ischemic stroke低分子量肝素治療中度急性腦中風
• 國科會研究計劃NMRP 9046, 2000-2001, 黃立同劉嘉為楊寧正, Effects of lithum-pilocarpine induced status epilepticus in pubercent rats: place cell physiology of hippocampus, histological and behavioral consequences, 新生老鼠抽搐後的智能學習及行為障礙長期研究及抗癲癇藥物治療之效果(NSC-89-2314-B-182A-143)
• 廠商贊助研究計劃XMRP 019, 2000, 劉嘉為許錦田, A multicenter, double-blind, randomized, placebo controlled, parellel group study of the efficacy and safety of oral eletriptan in subjects with acute migraine, Eletriptan 在急性偏頭痛發作之療效：多醫學中心之雙盲，任意及安慰劑實驗
• 長庚研究計劃CMRP 1135, 2001/4-2002/4, 劉嘉為黃立同楊寧正Neuroprotective Effect of Brain-derived Neurotrophic Factors in Histologic Damage and Cognitive Impairment due to Kainic Acid Induced Seizure.
• 財團法人醫療促進基金會, 2000-2001, 黃立同劉嘉為王慈柔, 楊寧正Neuroprotective effect of brain-derived neurotrophic factors in histologic damage and cognitive impairment due to kainic acid induced seizure.
• 國科會研究計劃NMRP, 2001/8-2002/7, 劉嘉為劉燦榮呂鎮中張谷州郭葉麟黃立同, The role of antioxidant activity in cerebral ischemic stroke, 急性腦梗塞時腦血管內抗氧化物所扮演的角色(NSC-90-2314-B-182A-062)
• 國科會研究計劃NMRP, 2001/8-2002/7, 劉嘉為陳偉熹刑福柳張谷州, The role of chlamydia pneumoniae infection and derangement of immunological profile in the development of atherosclerotic disease and subsequent stroke in young patients, 肺炎披衣菌感染及血管發炎免疫反應在年輕型中風病人血管粥腫樣硬化繼發生腦血管阻塞疾病之角色(NSC-90-2314-B-182A-079)
• 長庚研究計劃CMRP, 2002/1-2002/12, 楊生湳黃立同劉嘉為, Modulation of dapamin D1/D5 receptors on glutamatergic synaptic plasticity in the hippocampus – development of therapeutic strategies (from genetics to behaviors) for the improvement of learning and memory ability in cerebral memtal retardation children’ 多巴銨甲型受體對中樞海馬迴神經麩氨酸突觸可塑性之調控作用研發從基因到行為治療中樞智障兒之學習與記憶研究
• 廠商贊助研究計劃XMRP 124, 2002-2004, 劉嘉為, BNG-1 in the recovery of ischemic stroke: A phase II, double-blind, placebo-controlled randomized trial. BNG-1 對缺血性中風病人之作用的phase II、隨機、雙盲、對照研究
• 國科會研究計劃NMRP, 2002/8-2003/7, 劉嘉為王佩文翁旭惠, The role of mitochondrial DNA 16189 polymorphism in the pathogenesis of type 2 diabetes mellitus complicating cerebral infarction, 粒線體基因第16189點之多形性變異與第2型糖尿病併腦血管梗塞之相關性研究(NSC-91-2314-B-182A-040)
• 國科會研究計劃NMRP, 2002/8-2003/7, 劉嘉為刑福柳張谷州陳廷耀, The role of chlamydia pneumoniae infection and derangement of immunological profile in the development of atherosclerotic disease and subsequent stroke in young patients, 肺炎披衣菌感染及血管發炎免疫反應在年輕型中風病人血管粥腫樣硬化繼發生腦血管阻塞疾病之角色(NSC-91-2314-B-182A-048)
• 國科會研究計劃NMRP, 2002/8-2003/7, 葉漢根陳勉成劉嘉為, 腦中風患者之血小板活性, 內皮細胞功能及發炎介質之時間性變化(NSC-91-2314-B-182A-062)
• 國科會研究計劃NMRP, 2002/8-2003/7,王珮文 劉嘉為 王新台, 第2型糖尿病致病機轉與粒線體質與量變異之研究(NSC-91-2314-B-182A-132)
• 國科會研究計劃NMRP, 2003/8-2004/7, 劉嘉為王佩文林祖功, The pathogenesis of mitochondrial DNA 16189 polymorphism in generation of type 2 diabetes mellitus complicating cerebral infarction, 粒線體基因第16189點核?酸之多形性變異與第2型糖尿病併腦血管梗塞相關性之機轉研究(NSC-92-2314-B-182A-119)
• 國科會研究計劃NMRP, 2003/8-2004/7,林祖功 莊曜聰 劉嘉為 陳尚德 張谷州, 以粒腺體呼吸氧化脢抑制劑rotenone引起之大白鼠巴金森氏症之神經細胞死亡之機轉(NSC-92-2314-B-182A-126)
• 國科會研究計劃NMRP, 2003/8-2004/7, 莊曜聰陳慶鏗 林祖功 陳尚德 劉嘉為, 癲癇重積狀態後顳葉粒腺體呼吸鏈功能變化之研究 (NSC-92-2314-B-182A-170)
• 國科會研究計劃NMRP, 2003/8-2004/7, 葉淑惠楊崑德劉嘉為王佩文, 太極拳對糖尿病患者及葡萄糖耐受性受損者的血糖控制、免疫功能、心肺功能、周邊神經病變之影響II(NSC-92-2314-B-182A-)
• 長庚研究計劃CMRP, 2003/9-2004/8, 陳尚德劉嘉為林祖功 黃致任, 炎性基因多型性變異和造成阿茲海默氏症的關聯(CMRPG8052)
• 長庚研究計劃CMRP, 2003/9-2004/8, 林祖功劉嘉為王佩文, 粒線體基因第16189點核?酸之多形性變異與血中GSH濃度對第2型糖尿病併腦血管梗塞之影響(CMRPG8056)
• 長庚研究計劃CMRP, 2003/9-2004/8, 王佩文 鄭汝紛 劉嘉為, 以肝臟內脂肪含量為指標來探討PPARr 基因多型性與粒線體基因之交互作用對Metabolic Syndrome(CMRPG80 )
• 國科會研究計劃NMRP, 2004/8-2005/7, 陳尚德 莊曜聰 劉嘉為 林祖功, 探討PPARγ/UCP2訊息路徑及粒腺體的功能障礙在暫時性全腦缺血造成海馬回CA1神經細胞死亡的角色及PPARγ活化劑神經保護功能對此路徑的作用(NSC-93-2314-B-182A-164)
• 國科會研究計劃NMRP, 2004/8-2005/7, 劉嘉為 王佩文 林祖功 陳尚德, 粒線體基因併細胞核PGC-1基因變異對國人因身體質量(BMI)增加伴隨糖尿病、腦血管梗塞發生率增加之相互關係研究(NSC-93-2314-B-182A-176)
• 國科會研究計劃NMRP, 2004/8-2005/7, 葉漢根 劉嘉為 陳庭耀, 心房纖維顫動併發腦中風患者血小板活性之時間性之變化,發炎介質,及可測量的栓塞血塊之發生頻率：探討抗血栓及抗血小板活性藥物的調節角色(NSC-93-2314-B-182A-)

Publications:

1.Liou CW, Chang CS, Chen HJ, Lui CC, Chen L. Delayed intracranial aneurysm of left atrial myxoma --- a case report. Chang Gung Med J 1990;13: 231-236.

2.Liou CW, ChuNS, Ryu SJ. CT, somatosensory and brainstem auditory evoked potentials in putaminal hemorrhage. Acta Neurol Scand 1991;84:28-32. (SCI)

3.Chen HJ, Liou CW, Leung C. Metastatic atrial myxoma presenting as intracranial aneurysms with hemorrhage: Case report. Surg Neurol 1993;40:61-64. (SCI)

4.Tsai SC, Chen HJ, Liou CW, Lui CC. Giant Sphenoid Sinus Mucocele With Visual Disturbance: Report of A Case. Acta Neurol Sin 1994;3:156-159.

5.Liou CW, Huang CC, Chee CY, Jong YJ, Tsai JL, Pang CY, Lee HC, Wei YH. MELAS syndrome: Correlation between clinical features and molecular genetic analysis. Acta Nuerol Scand 1994;90:354-359. (SCI)

6.Huang CC, Wai YY, ChuNS, Liou CW, Pang CY, Shih KD, Wei YH. Mitochondrial encephalomyopathies: CT and MRI findings and correlations with clinical features. Euro Neurol 1995;35:199-205. (SCI)

7.Chiou NM, Liou CW. Psychiatric manifestations in a patient with idiopathic hypoparathyroidism combined with mental retardation. Taiwanese J Psychi. 1997;11:202-208.

8.Huang CR, Chang WN, Lui CC, Wu HS, Liou CW. Neuroimages of Japanese Encephalitis: Report of Three Patients. Chin Med J (Taipei) 1997;60:105-108

9.Chang GC, Liou CW, Cheng SD. Non-O1 cholera bacteremia and meningitis: Report of a case. Acta Neurol Sin 1998;7:114-118. (correspondence)

10.Lu CH, ChenSD, Liou CW, Chiu ST. Application of duplex and transcranial doppler in diagnosing arteriovenous malformation: Report of a case. J Med Ultrasound 1998;6:200-203.

11.Tan TY, Lui CC, Chen HJ, Liou CW. Cerebral sparganosis: case report. Chang Gung Med J 1999;22:287-292. (correspondence)

12.Liou CW, Huang CC, Tsai JL, Liu JY, Pang CY, Lee HC, Wang EK, Wei YH. Absence of maternal A3243G mitochondrial mutation and reversible hyperglycemia in a patient with MELAS syndrome. Acta Neurol Scand 2000;101:65-69. (SCI)

13.Liou CW, Huang CC, Lin TK, Tsai JL, Wei YH. Correction of pancreatic beta-cell dysfunction with coenzyme Q10 in a patient with MELAS syndrome and diabetes mellitus. Euro Neurol 2000;43:54-55. (SCI)

14.Wong WJ, Hu HH, Lukl YO, Cherng CM, Lien LM, Chen JR, Chiu HC, Ann MY, Jong GP, Kuo TH, Chang KC, Tan TY, Liou CW. Intravenous thrombolytic therapy in acute ischemic stroke in Taiwan. Taiwan Crit. Care Med. 2001;3:112-120.

15.Wu CL, Huang LT, Liou CW, Wang TJ, Tung YR, Hsu HY, Lai MC. Lithium-Pilocarpine-Induced status epilepticus in immature rats: Long-term effects on spatial leraning, motor, and morphology. Neurscience letter 2001;312:113-117. (SCI)

16.Liou CW, Lui CC, Cheng MH. A case of intracerebral abscess caused by non-O1 vibrio cholera. Eur J Clin Microbiol 2001;20:678-680. (SCI)

17.Tan TY, Chang GC, Liou CW. Lack of relation between severity of stroke and severity of extracranial internal carotid artery lesions in Taiwanese first-ever ischemic stroke patients. J Neuroimaging 2001;11:381-384 (SCI)

18.Liou CW, Huang CC, Wei YH. Molecular analysis of diabetes mellitus- associated A3243G mitochondrial mutation in Taiwanese cases. Diab Res Clin Prac 2001;54:S39-S43. (SCI)

19.Wang PW, Liou CW, Wang ST, Eng HL, Chien WY, Lu YC, Kuo MC, Hsieh JR, Reaven GM. Relative impact of low-density lipoprotein- cholesterol concentration and insulin resistance on carotid wall thickening in nondiabetic, normotensive volunteers. Metabolism 2002;51:255-259. (SCI)

20.Huang LT, Liou CW, Yang SN, Lai MC, HungPL, WangTJ, ChengSC, Wu CL. Aminophylline Aggravates Long-term Morphological and Cognitive Damages in Status Epilepticus in Immature Rats.Neurscience letter 2002;321:137-140. (SCI)

21.Lai MC, Liou CW, Yang SN, Wang CL, Hung PL, Wu CW, Tung YR, Huang LT. Recurrent bicuculline-induced seizures in rat pups cause long-term motor deficits and increase vulnerability to subsequent insult. Epilepsy Behavior 2002;3:60-66.

22.Huang LT, Yang SN, Liou CW, Hung PL, Lai MC, Wang CL, Wang TJ. Pentylenetetrazol-induced recurrent seizures in rat pups: time course on sparial learning and long-term effects. Epilepsia 2002;43:567-573. (SCI)

23.Hung PL, Lai MC, Yang SN, Wang CL, Liou CW, Wu CL, Wang TJ, Huang LT. Aminophyllin exacerbates status epilepticus-induced neuronal damages in immature rats: a morphological, motor and behavioral study. Epilepsy Research 2002;49:218-225. (SCI)

24.Tan TY, Chang KC, Liou CW. Factors Delaying Hospital Arrival after Acute Stroke in Taiwan. Chang Gung Med J 2002;25:458-463.

25.Chuang YC, Tsai JL, Chang AYW, Chan JYH, Liou CW, Chan SHH. Dysfunction of Mitochondrial Respiratory Chain in Rostral Ventrolateral Medulla During Experimental Endotoxemia in the Rat. J Biomedical Science 2002;9:542-549. (SCI)

26.Huang CC, Kuo HC, Chu CC, Liou CW, Ma YS, Wei YH. Clinical Phenotype, Prognosis and Mitochondrial DNA Mutation Load in Mitochondrial Encephalomyopathies. J Biomed Sci 2002;9:527-533. (SCI)

27.Huang LT, Holmes GL, Lai MC, Hung PL, Wang CL, Wang TZ, Yang CH, Liou CW, Yang SN. Maternal deprivation stress exacerbates cognitive deficits in immature rats with recurrent seizures. Epilepsia 2002;43:1141-1148. (SCI)

28.Chang KC, Tseng MC, Weng HH, Lin YH, Liou CW, Tan TY. Prediction of length of stay of first-ever ischemic stroke. Stroke 2002;33:2670-2674. (SCI)

• Tsay TH, Leong CP, Lau YC,Liou CW, Hsu TY. The prognosis of stroke during pregnancy. J Rehab Med Assoc ROC 2002; 30:131-140
• Chuang YC, Chan JYH, Chang AYW, Sikorska M, Liou CW, Chan SHH. Neuroprotective effects of coenzyme Q10 at rostral ventrolateral medulla against fatality during experimental endotoxemia in the rat. Shock 2003; 19:427-432. (SCI)
• Liou CW, Huang CC, Tsai JL, Wei YW. Low antioxidant content and mutation load in mitochondrial DNA A3243G mutation related diabetes mellitus. J Formos Med Assoc 2003;102:527-533. (SCI)
• Huang LT, Lai MC, Wang CL, Wang CA, Yang CH, Hsieh CS, Liou CW, Yang SN. Long-term effects of early-life malnutrition and status epilepticus: assessment by spatial navigation and CREB(Serine-133) phosphorylation.Dev Brain Res. 2003;12;:213-8. (SCI)
• Tsai YH, Shih SW, Chang KC, Liou CW, Kuo YL, Lui CC, Lee RJ, Lee YC, Chiu KC. Angioplasty with stenting in treatment of carotid artery stenosis: report of 3-year series. Chin J Radiol 2003; 28: 361-366.
• Huang LT, Hsieh CS, Chou MH, Chuang JH,Liou CW, Tiao MM, Lai MC. Obstructive jaundice in rats: cause of spatial memory deficits with recovery after biliary decompression. World J Surg. 2004; 28: 283-287. (SCI)
• Liou CW, Lin TK, Huang FM, Chen TL, Lee CF, Chuang YC, Tan TW, Chang KC, Wei YH. Association of a mitochondrial DNA 16189 np variant with lacunar cerebral infarction: evidence from a hospital based case-control study. Ann NY Acad Sci 2004; 1011:317-324. (SCI)
• Chen YN, Liou CW, Huang CC, Lin TK, Wei YW. Maternally inherited diabetes and deafness (MIDD) syndrome: the clinical and molecular genetic study of a Taiwanese family. Chang Gung Med J 2004;27:64-71. (correspondence)
• Tan TY, Liou CW, Kung LC. Persistent Neutrophilic Meningitis Caused byPseudallescheria boydii Infection: A Case Report. Chang Gung Med J 2004; 27:228-232. (correspondence)
• Chang CS, Liou CW, Huang CC, Lui CC, Chang KC. Carvenous sinus thrombosis and stroke after fusobacterial nucleatum infection. Chang Gung Med J 2004; 27:443-447. (correspondence)
• Chou YJ, Ou CY, Hsu TY, Liou CW, Lee HC, Tso YH, Wei YH. Prenatal diagnosis of a fetus harboring intermediate load of A3243G mtDNA mutation from a maternal carrier diagnosed with MELAS Syndrome. Prenatal Diagnosis 2004:24:367-370.(SCI) (correspondence)
• Tan TY, Chang KC, MC Tseng, Liou CW. Risk factors for ischemic stroke: A case-control study in Taiwan. Acta Neurol Scand 2004 (in press) (SCI)
• Chen CH, Lo YK, Ke DS, Liu CK, Liou CW, Lai ML. Platelet glycoprotein Ia C807T, Ib C3550T, and IIIa PlA1/A2 polymorphisms and ischemic stroke in young Taiwanese. J Neuro Science 2004 (in press) (SCI)
• Tan YY, Chang KC, Liou CW, Schminke U. Low prevalence of significant extracranial carotid atherosclerosis in Taiwanese first-ever ischemic stroke patients. J Clin Ultrasound 2004 (in press) (SCI)
• Lin TK,Chen SD,Wang PW, Wei YH, Lee CF, Chen TZ, Lee CF, Chuang YC, Tan TY, Chang KC, Liou CW. Increased Oxidative Damage with Altered Antioxidative Status in Type 2 Diabetic Patients Harboring the 16189 T to C Variant of Mitochondrial DNA. Ann NY Acad Sci 2004 (in press) correspondence (SCI)